ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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T-cell surface protein tactile

Intramolecular
Cysteine 79 and cysteine 85
Cysteine 45 and cysteine 118
A redox-regulated disulphide may form within T-cell surface protein tactile between cysteines 79 and 85.

Details

Redox score ?
87
PDB code
6arq
Structure name
crystal structure of cd96 (d1) bound to cd155/necl-5 (d1-3)
Structure deposition date
2017-08-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
P40200
Residue number A
79
Residue number B
85
Peptide name
T-cell surface protein tactile

Ligandability

Cysteine 79 of T-cell surface protein tactile

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 85 of T-cell surface protein tactile

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell surface protein tactile between cysteines 45 and 118.

Details

Redox score ?
80
PDB code
6arq
Structure name
crystal structure of cd96 (d1) bound to cd155/necl-5 (d1-3)
Structure deposition date
2017-08-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P40200
Residue number A
45
Residue number B
118
Peptide name
T-cell surface protein tactile

Ligandability

Cysteine 45 of T-cell surface protein tactile

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 118 of T-cell surface protein tactile

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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