Signal transducer and activator of transcription 3

Intramolecular

A redox-regulated disulphide may form within Signal transducer and activator of transcription 3 between cysteines 251 and 328. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

6tlc

Structure name

unphosphorylated human stat3 in complex with ms3-6 monobody

Structure deposition date

2019-12-02

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

P40763

Residue number A

251

Residue number B

328

Peptide name

Signal transducer and activator of transcription 3

Ligandability

Cysteine 251 of Signal transducer and activator of transcription 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 328 of Signal transducer and activator of transcription 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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