Ubiquitin carboxyl-terminal hydrolase 8
Intramolecular
Cysteine 936 and cysteine 985
Cysteine 936 and cysteine 988
Cysteine 936 and cysteine 939
Cysteine 939 and cysteine 985
Cysteine 985 and cysteine 988
Cysteine 939 and cysteine 988
Cysteine 962 and cysteine 967
Cysteine 794 and cysteine 1072
Cysteine 796 and cysteine 1072
Cysteine 794 and cysteine 796
2gfo A 936 A 985
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 8 between cysteines 936 and 985.
Details
Redox score ?
88
PDB code
2gfo
Structure name
structure of the catalytic domain of human ubiquitin carboxyl-terminal hydrolase 8
Structure deposition date
2006-03-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
6
% buried
0
Peptide accession
P40818
Residue number A
936
Residue number B
985
Peptide name
Ubiquitin carboxyl-terminal hydrolase 8
Ligandability
Cysteine 936 of Ubiquitin carboxyl-terminal hydrolase 8
Cysteine 985 of Ubiquitin carboxyl-terminal hydrolase 8
2gfo A 936 A 988
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 8 between cysteines 936 and 988.
Details
Redox score ?
87
PDB code
2gfo
Structure name
structure of the catalytic domain of human ubiquitin carboxyl-terminal hydrolase 8
Structure deposition date
2006-03-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
6
% buried
0
Peptide accession
P40818
Residue number A
936
Residue number B
988
Peptide name
Ubiquitin carboxyl-terminal hydrolase 8
Ligandability
Cysteine 936 of Ubiquitin carboxyl-terminal hydrolase 8
Cysteine 988 of Ubiquitin carboxyl-terminal hydrolase 8
3n3k A 936 A 939
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 8 between cysteines 936 and 939.
Details
Redox score ?
86
PDB code
3n3k
Structure name
the catalytic domain of usp8 in complex with a usp8 specific inhibitor
Structure deposition date
2010-05-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
5
% buried
3
Peptide accession
P40818
Residue number A
936
Residue number B
939
Peptide name
Ubiquitin carboxyl-terminal hydrolase 8
Ligandability
Cysteine 936 of Ubiquitin carboxyl-terminal hydrolase 8
Cysteine 939 of Ubiquitin carboxyl-terminal hydrolase 8
2gfo A 939 A 985
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 8 between cysteines 939 and 985.
Details
Redox score ?
85
PDB code
2gfo
Structure name
structure of the catalytic domain of human ubiquitin carboxyl-terminal hydrolase 8
Structure deposition date
2006-03-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
7
% buried
0
Peptide accession
P40818
Residue number A
939
Residue number B
985
Peptide name
Ubiquitin carboxyl-terminal hydrolase 8
Ligandability
Cysteine 939 of Ubiquitin carboxyl-terminal hydrolase 8
Cysteine 985 of Ubiquitin carboxyl-terminal hydrolase 8
3n3k A 985 A 988
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 8 between cysteines 985 and 988.
Details
Redox score ?
84
PDB code
3n3k
Structure name
the catalytic domain of usp8 in complex with a usp8 specific inhibitor
Structure deposition date
2010-05-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
8
% buried
4
Peptide accession
P40818
Residue number A
985
Residue number B
988
Peptide name
Ubiquitin carboxyl-terminal hydrolase 8
Ligandability
Cysteine 985 of Ubiquitin carboxyl-terminal hydrolase 8
Cysteine 988 of Ubiquitin carboxyl-terminal hydrolase 8
2gfo A 939 A 988
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 8 between cysteines 939 and 988.
Details
Redox score ?
79
PDB code
2gfo
Structure name
structure of the catalytic domain of human ubiquitin carboxyl-terminal hydrolase 8
Structure deposition date
2006-03-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
38
Minimum pKa ?
9
% buried
0
Peptide accession
P40818
Residue number A
939
Residue number B
988
Peptide name
Ubiquitin carboxyl-terminal hydrolase 8
Ligandability
Cysteine 939 of Ubiquitin carboxyl-terminal hydrolase 8
Cysteine 988 of Ubiquitin carboxyl-terminal hydrolase 8
3n3k A 962 A 967
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 8 between cysteines 962 and 967.
Details
Redox score ?
79
PDB code
3n3k
Structure name
the catalytic domain of usp8 in complex with a usp8 specific inhibitor
Structure deposition date
2010-05-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
38
Peptide accession
P40818
Residue number A
962
Residue number B
967
Peptide name
Ubiquitin carboxyl-terminal hydrolase 8
Ligandability
Cysteine 962 of Ubiquitin carboxyl-terminal hydrolase 8
Cysteine 967 of Ubiquitin carboxyl-terminal hydrolase 8
3n3k A 794 A 1072
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 8 between cysteines 794 and 1072.
Details
Redox score ?
64
PDB code
3n3k
Structure name
the catalytic domain of usp8 in complex with a usp8 specific inhibitor
Structure deposition date
2010-05-20
Thiol separation (Å)
5
Half-sphere exposure sum ?
96
Minimum pKa ?
8
% buried
100
Peptide accession
P40818
Residue number A
794
Residue number B
1072
Peptide name
Ubiquitin carboxyl-terminal hydrolase 8
Ligandability
Cysteine 794 of Ubiquitin carboxyl-terminal hydrolase 8
Cysteine 1072 of Ubiquitin carboxyl-terminal hydrolase 8
2gfo A 796 A 1072
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 8 between cysteines 796 and 1072. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
2gfo
Structure name
structure of the catalytic domain of human ubiquitin carboxyl-terminal hydrolase 8
Structure deposition date
2006-03-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
91
Minimum pKa ?
8
% buried
100
Peptide accession
P40818
Residue number A
796
Residue number B
1072
Peptide name
Ubiquitin carboxyl-terminal hydrolase 8
Ligandability
Cysteine 796 of Ubiquitin carboxyl-terminal hydrolase 8
Cysteine 1072 of Ubiquitin carboxyl-terminal hydrolase 8
3n3k A 794 A 796
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 8 between cysteines 794 and 796. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
27
PDB code
3n3k
Structure name
the catalytic domain of usp8 in complex with a usp8 specific inhibitor
Structure deposition date
2010-05-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
91
Minimum pKa ?
13
% buried
100
Peptide accession
P40818
Residue number A
794
Residue number B
796
Peptide name
Ubiquitin carboxyl-terminal hydrolase 8
Ligandability
Cysteine 794 of Ubiquitin carboxyl-terminal hydrolase 8
Cysteine 796 of Ubiquitin carboxyl-terminal hydrolase 8
If this tool was useful for finding a disulphide, please cite: