Malate dehydrogenase, mitochondrial
Intramolecular
Cysteine 128 and cysteine 132
Cysteine 93 and cysteine 132
Cysteine 89 and cysteine 93
Cysteine 89 and cysteine 132
Cysteine 93 and cysteine 128
Cysteine 89 and cysteine 128
Cysteine 128 and cysteine 138
4wle C 128 C 132
A redox-regulated disulphide may form within Malate dehydrogenase, mitochondrial between cysteines 128 and 132.
Details
Redox score ?
70
PDB code
4wle
Structure name
crystal structure of citrate bound mdh2
Structure deposition date
2014-10-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
8
% buried
88
Peptide accession
P40926
Residue number A
128
Residue number B
132
Peptide name
Malate dehydrogenase, mitochondrial
Ligandability
Cysteine 128 of Malate dehydrogenase, mitochondrial
Cysteine 132 of Malate dehydrogenase, mitochondrial
4wlv B 93 B 132
A redox-regulated disulphide may form within Malate dehydrogenase, mitochondrial between cysteines 93 and 132.
Details
Redox score ?
70
PDB code
4wlv
Structure name
crystal structure of nad bound mdh2
Structure deposition date
2014-10-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
67
Minimum pKa ?
8
% buried
74
Peptide accession
P40926
Residue number A
93
Residue number B
132
Peptide name
Malate dehydrogenase, mitochondrial
Ligandability
Cysteine 93 of Malate dehydrogenase, mitochondrial
Cysteine 132 of Malate dehydrogenase, mitochondrial
4wlo A 89 A 93
A redox-regulated disulphide may form within Malate dehydrogenase, mitochondrial between cysteines 89 and 93. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
4wlo
Structure name
crystal structure of oxaloacetate and nadh bound mdh2
Structure deposition date
2014-10-07
Thiol separation (Å)
6
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
82
Peptide accession
P40926
Residue number A
89
Residue number B
93
Peptide name
Malate dehydrogenase, mitochondrial
Ligandability
Cysteine 89 of Malate dehydrogenase, mitochondrial
Cysteine 93 of Malate dehydrogenase, mitochondrial
4wln C 89 C 132
A redox-regulated disulphide may form within Malate dehydrogenase, mitochondrial between cysteines 89 and 132. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
4wln
Structure name
crystal structure of apo mdh2
Structure deposition date
2014-10-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
8
% buried
80
Peptide accession
P40926
Residue number A
89
Residue number B
132
Peptide name
Malate dehydrogenase, mitochondrial
Ligandability
Cysteine 89 of Malate dehydrogenase, mitochondrial
Cysteine 132 of Malate dehydrogenase, mitochondrial
4wlo C 93 C 128
A redox-regulated disulphide may form within Malate dehydrogenase, mitochondrial between cysteines 93 and 128. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
4wlo
Structure name
crystal structure of oxaloacetate and nadh bound mdh2
Structure deposition date
2014-10-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
85
Peptide accession
P40926
Residue number A
93
Residue number B
128
Peptide name
Malate dehydrogenase, mitochondrial
Ligandability
Cysteine 93 of Malate dehydrogenase, mitochondrial
Cysteine 128 of Malate dehydrogenase, mitochondrial
4wlu B 89 B 128
A redox-regulated disulphide may form within Malate dehydrogenase, mitochondrial between cysteines 89 and 128. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
4wlu
Structure name
crystal structure of l-malate and nad bound mdh2
Structure deposition date
2014-10-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
12
% buried
96
Peptide accession
P40926
Residue number A
89
Residue number B
128
Peptide name
Malate dehydrogenase, mitochondrial
Ligandability
Cysteine 89 of Malate dehydrogenase, mitochondrial
Cysteine 128 of Malate dehydrogenase, mitochondrial
4wle A 128 A 138
A redox-regulated disulphide may form within Malate dehydrogenase, mitochondrial between cysteines 128 and 138. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
23
PDB code
4wle
Structure name
crystal structure of citrate bound mdh2
Structure deposition date
2014-10-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
90
Minimum pKa ?
13
% buried
100
Peptide accession
P40926
Residue number A
128
Residue number B
138
Peptide name
Malate dehydrogenase, mitochondrial
Ligandability
Cysteine 128 of Malate dehydrogenase, mitochondrial
Cysteine 138 of Malate dehydrogenase, mitochondrial
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