ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Replication factor C subunit 3

Intermolecular
Cysteine 285 and cysteine 540 of Cell cycle checkpoint protein RAD17
Intramolecular
Cysteine 200 and cysteine 230 L
Cysteine 230 and cysteine 233 L
Cysteine 11 and cysteine 54
Cysteine 200 and cysteine 233 L
Cysteine 193 and cysteine 200 L
Cysteine 164 and cysteine 165
Cysteine 165 and cysteine 179
A redox-regulated disulphide may form between cysteine 285 of Replication factor C subunit 3 and cysteine 540 of Cell cycle checkpoint protein RAD17.

Details

Redox score ?
61
PDB code
7z6h
Structure name
structure of dna-bound human rad17-rfc clamp loader and 9-1-1 checkpoint clamp
Structure deposition date
2022-03-11
Thiol separation (Å)
6
Half-sphere exposure sum ?
74
Minimum pKa ?
10
% buried
58
Peptide A name
Replication factor C subunit 3
Peptide B name
Cell cycle checkpoint protein RAD17
Peptide A accession
P40938
Peptide B accession
O75943
Peptide A residue number
285
Peptide B residue number
540

Ligandability

Cysteine 285 of Replication factor C subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 540 of Cell cycle checkpoint protein RAD17

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Replication factor C subunit 3 between cysteines 200 and 230.

Details

Redox score ?
74
PDB code
6vvo
Structure name
structure of the human clamp loader (replication factor c, rfc) bound to the sliding clamp (proliferating cell nuclear antigen, pcna)
Structure deposition date
2020-02-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
8
% buried
78
Peptide accession
P40938
Residue number A
200
Residue number B
230
Peptide name
Replication factor C subunit 3

Ligandability

Cysteine 200 of Replication factor C subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 230 of Replication factor C subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Replication factor C subunit 3 between cysteines 230 and 233. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
6vvo
Structure name
structure of the human clamp loader (replication factor c, rfc) bound to the sliding clamp (proliferating cell nuclear antigen, pcna)
Structure deposition date
2020-02-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
73
Minimum pKa ?
12
% buried
80
Peptide accession
P40938
Residue number A
230
Residue number B
233
Peptide name
Replication factor C subunit 3

Ligandability

Cysteine 230 of Replication factor C subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 233 of Replication factor C subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Replication factor C subunit 3 between cysteines 11 and 54. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
6vvo
Structure name
structure of the human clamp loader (replication factor c, rfc) bound to the sliding clamp (proliferating cell nuclear antigen, pcna)
Structure deposition date
2020-02-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
58
Minimum pKa ?
9
% buried
55
Peptide accession
P40938
Residue number A
11
Residue number B
54
Peptide name
Replication factor C subunit 3

Ligandability

Cysteine 11 of Replication factor C subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 54 of Replication factor C subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Replication factor C subunit 3 between cysteines 200 and 233. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
6vvo
Structure name
structure of the human clamp loader (replication factor c, rfc) bound to the sliding clamp (proliferating cell nuclear antigen, pcna)
Structure deposition date
2020-02-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
57
Minimum pKa ?
8
% buried
63
Peptide accession
P40938
Residue number A
200
Residue number B
233
Peptide name
Replication factor C subunit 3

Ligandability

Cysteine 200 of Replication factor C subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 233 of Replication factor C subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Replication factor C subunit 3 between cysteines 193 and 200. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
6vvo
Structure name
structure of the human clamp loader (replication factor c, rfc) bound to the sliding clamp (proliferating cell nuclear antigen, pcna)
Structure deposition date
2020-02-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
8
% buried
43
Peptide accession
P40938
Residue number A
193
Residue number B
200
Peptide name
Replication factor C subunit 3

Ligandability

Cysteine 193 of Replication factor C subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 200 of Replication factor C subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Replication factor C subunit 3 between cysteines 164 and 165. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
6vvo
Structure name
structure of the human clamp loader (replication factor c, rfc) bound to the sliding clamp (proliferating cell nuclear antigen, pcna)
Structure deposition date
2020-02-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
84
Minimum pKa ?
13
% buried
100
Peptide accession
P40938
Residue number A
164
Residue number B
165
Peptide name
Replication factor C subunit 3

Ligandability

Cysteine 164 of Replication factor C subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 165 of Replication factor C subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Replication factor C subunit 3 between cysteines 165 and 179. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
6vvo
Structure name
structure of the human clamp loader (replication factor c, rfc) bound to the sliding clamp (proliferating cell nuclear antigen, pcna)
Structure deposition date
2020-02-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
12
% buried
100
Peptide accession
P40938
Residue number A
165
Residue number B
179
Peptide name
Replication factor C subunit 3

Ligandability

Cysteine 165 of Replication factor C subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 179 of Replication factor C subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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