ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Eukaryotic translation initiation factor 2 subunit 3

Intramolecular
Cysteine 96 and cysteine 236
A redox-regulated disulphide may form within Eukaryotic translation initiation factor 2 subunit 3 between cysteines 96 and 236. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
6k72
Structure name
eif2(ap) - eif2b complex
Structure deposition date
2019-06-05
Thiol separation (Å)
6
Half-sphere exposure sum ?
81
Minimum pKa ?
9
% buried
100
Peptide accession
P41091
Residue number A
96
Residue number B
236
Peptide name
Eukaryotic translation initiation factor 2 subunit 3

Ligandability

Cysteine 96 of Eukaryotic translation initiation factor 2 subunit 3

Cysteine 236 of Eukaryotic translation initiation factor 2 subunit 3

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