ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Delta-type opioid receptor

Intramolecular
Cysteine 121 and cysteine 198
Cysteine 151 and cysteine 232
Cysteine 216 and cysteine 232
A redox-regulated disulphide may form within Delta-type opioid receptor between cysteines 121 and 198.

Details

Redox score ?
85
PDB code
4ej4
Structure name
structure of the delta opioid receptor bound to naltrindole
Structure deposition date
2012-04-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P32300
Residue number A
121
Residue number B
198
Peptide name
Delta-type opioid receptor

Ligandability

Cysteine 121 of Delta-type opioid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 198 of Delta-type opioid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Delta-type opioid receptor between cysteines 151 and 232. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
4ej4
Structure name
structure of the delta opioid receptor bound to naltrindole
Structure deposition date
2012-04-06
Thiol separation (Å)
8
Half-sphere exposure sum ?
56
Minimum pKa ?
9
% buried
28
Peptide accession
P32300
Residue number A
151
Residue number B
232
Peptide name
Delta-type opioid receptor

Ligandability

Cysteine 151 of Delta-type opioid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 232 of Delta-type opioid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Delta-type opioid receptor between cysteines 216 and 232 (143 and 232 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
8f7s
Structure name
gi bound delta-opioid receptor in complex with deltorphin
Structure deposition date
2022-11-20
Thiol separation (Å)
7
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
78
Peptide accession
P41143
Residue number A
216
Residue number B
232
Peptide name
Delta-type opioid receptor

Ligandability

Cysteine 216 of Delta-type opioid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 232 of Delta-type opioid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: