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Isoform 1 of Extracellular calcium-sensing receptor

Intermolecular
Cysteine 131 and cysteine 131
Cysteine 129 and cysteine 129
Intramolecular
Cysteine 585 and cysteine 598
Cysteine 358 and cysteine 395
Cysteine 437 and cysteine 449
Cysteine 568 and cysteine 582
Cysteine 546 and cysteine 565
Cysteine 677 and cysteine 765
Cysteine 60 and cysteine 101
Cysteine 542 and cysteine 562
More...
Cysteine 236 and cysteine 561
Cysteine 129 and cysteine 131
Cysteine 561 and cysteine 562
Cysteine 661 and cysteine 691
Cysteine 542 and cysteine 561
Cysteine 236 and cysteine 562
Cysteine 568 and cysteine 585
Cysteine 236 and cysteine 542
Cysteine 691 and cysteine 694
Cysteine 660 and cysteine 661
Cysteine 546 and cysteine 582
Cysteine 546 and cysteine 568
Cysteine 582 and cysteine 598
Cysteine 582 and cysteine 585
Cysteine 660 and cysteine 694
Cysteine 568 and cysteine 598
Cysteine 565 and cysteine 582
Cysteine 731 and cysteine 787
Cysteine 546 and cysteine 562
Cysteine 660 and cysteine 691
Cysteine 562 and cysteine 565
Cysteine 694 and cysteine 731
Cysteine 661 and cysteine 694
Cysteine 691 and cysteine 787
Cysteine 694 and cysteine 787
A redox-regulated disulphide may form between two units of Isoform 1 of Extracellular calcium-sensing receptor at cysteines 131 and 131.

Details

Redox score ?
75
PDB code
7sin
Structure name
structure of negative allosteric modulator-bound inactive human calcium-sensing receptor
Structure deposition date
2021-10-14
Thiol separation (Å)
5
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide A name
Isoform 1 of Extracellular calcium-sensing receptor
Peptide B name
Isoform 1 of Extracellular calcium-sensing receptor
Peptide A accession
P41180-1
Peptide B accession
P41180-1
Peptide A residue number
131
Peptide B residue number
131

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Isoform 1 of Extracellular calcium-sensing receptor at cysteines 129 and 129.

Details

Redox score ?
67
PDB code
7sin
Structure name
structure of negative allosteric modulator-bound inactive human calcium-sensing receptor
Structure deposition date
2021-10-14
Thiol separation (Å)
5
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide A name
Isoform 1 of Extracellular calcium-sensing receptor
Peptide B name
Isoform 1 of Extracellular calcium-sensing receptor
Peptide A accession
P41180-1
Peptide B accession
P41180-1
Peptide A residue number
129
Peptide B residue number
129

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 1 of Extracellular calcium-sensing receptor between cysteines 585 and 598.

Details

Redox score ?
89
PDB code
7sim
Structure name
structure of positive allosteric modulator-free active human calcium- sensing receptor
Structure deposition date
2021-10-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41180-1
Residue number A
585
Residue number B
598
Peptide name
Isoform 1 of Extracellular calcium-sensing receptor

Ligandability

Cysteine 585 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 598 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 1 of Extracellular calcium-sensing receptor between cysteines 358 and 395.

Details

Redox score ?
89
PDB code
7sil
Structure name
structure of positive allosteric modulator-bound active human calcium- sensing receptor
Structure deposition date
2021-10-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
38
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41180-1
Residue number A
358
Residue number B
395
Peptide name
Isoform 1 of Extracellular calcium-sensing receptor

Ligandability

Cysteine 358 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 395 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 1 of Extracellular calcium-sensing receptor between cysteines 437 and 449.

Details

Redox score ?
87
PDB code
7sil
Structure name
structure of positive allosteric modulator-bound active human calcium- sensing receptor
Structure deposition date
2021-10-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41180-1
Residue number A
437
Residue number B
449
Peptide name
Isoform 1 of Extracellular calcium-sensing receptor

Ligandability

Cysteine 437 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 449 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 1 of Extracellular calcium-sensing receptor between cysteines 568 and 582.

Details

Redox score ?
87
PDB code
7sim
Structure name
structure of positive allosteric modulator-free active human calcium- sensing receptor
Structure deposition date
2021-10-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41180-1
Residue number A
568
Residue number B
582
Peptide name
Isoform 1 of Extracellular calcium-sensing receptor

Ligandability

Cysteine 568 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 582 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 1 of Extracellular calcium-sensing receptor between cysteines 546 and 565.

Details

Redox score ?
86
PDB code
7sin
Structure name
structure of negative allosteric modulator-bound inactive human calcium-sensing receptor
Structure deposition date
2021-10-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41180-1
Residue number A
546
Residue number B
565
Peptide name
Isoform 1 of Extracellular calcium-sensing receptor

Ligandability

Cysteine 546 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 565 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 1 of Extracellular calcium-sensing receptor between cysteines 677 and 765.

Details

Redox score ?
86
PDB code
7sin
Structure name
structure of negative allosteric modulator-bound inactive human calcium-sensing receptor
Structure deposition date
2021-10-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41180-1
Residue number A
677
Residue number B
765
Peptide name
Isoform 1 of Extracellular calcium-sensing receptor

Ligandability

Cysteine 677 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 765 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 1 of Extracellular calcium-sensing receptor between cysteines 60 and 101.

Details

Redox score ?
84
PDB code
7sim
Structure name
structure of positive allosteric modulator-free active human calcium- sensing receptor
Structure deposition date
2021-10-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41180-1
Residue number A
60
Residue number B
101
Peptide name
Isoform 1 of Extracellular calcium-sensing receptor

Ligandability

Cysteine 60 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 101 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 1 of Extracellular calcium-sensing receptor between cysteines 542 and 562.

Details

Redox score ?
84
PDB code
7sil
Structure name
structure of positive allosteric modulator-bound active human calcium- sensing receptor
Structure deposition date
2021-10-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41180-1
Residue number A
542
Residue number B
562
Peptide name
Isoform 1 of Extracellular calcium-sensing receptor

Ligandability

Cysteine 542 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 562 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 1 of Extracellular calcium-sensing receptor between cysteines 236 and 561.

Details

Redox score ?
80
PDB code
7sin
Structure name
structure of negative allosteric modulator-bound inactive human calcium-sensing receptor
Structure deposition date
2021-10-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41180-1
Residue number A
236
Residue number B
561
Peptide name
Isoform 1 of Extracellular calcium-sensing receptor

Ligandability

Cysteine 236 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 561 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 1 of Extracellular calcium-sensing receptor between cysteines 129 and 131.

Details

Redox score ?
72
PDB code
7sin
Structure name
structure of negative allosteric modulator-bound inactive human calcium-sensing receptor
Structure deposition date
2021-10-14
Thiol separation (Å)
5
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41180-1
Residue number A
129
Residue number B
131
Peptide name
Isoform 1 of Extracellular calcium-sensing receptor

Ligandability

Cysteine 129 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 131 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Extracellular calcium-sensing receptor between cysteines 561 and 562.

Details

Redox score ?
69
PDB code
5k5t
Structure name
crystal structure of the inactive form of human calcium-sensing receptor extracellular domain
Structure deposition date
2016-05-23
Thiol separation (Å)
5
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41180
Residue number A
561
Residue number B
562
Peptide name
Extracellular calcium-sensing receptor

Ligandability

Cysteine 561 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 562 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Extracellular calcium-sensing receptor between cysteines 661 and 691.

Details

Redox score ?
62
PDB code
7m3e
Structure name
asymmetric activation of the calcium sensing receptor homodimer
Structure deposition date
2021-03-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
83
Minimum pKa ?
9
% buried
100
Peptide accession
P41180
Residue number A
661
Residue number B
691
Peptide name
Extracellular calcium-sensing receptor

Ligandability

Cysteine 661 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 691 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Extracellular calcium-sensing receptor between cysteines 542 and 561.

Details

Redox score ?
60
PDB code
5k5s
Structure name
crystal structure of the active form of human calcium-sensing receptor extracellular domain
Structure deposition date
2016-05-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41180
Residue number A
542
Residue number B
561
Peptide name
Extracellular calcium-sensing receptor

Ligandability

Cysteine 542 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 561 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Extracellular calcium-sensing receptor between cysteines 236 and 562. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
5k5t
Structure name
crystal structure of the inactive form of human calcium-sensing receptor extracellular domain
Structure deposition date
2016-05-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41180
Residue number A
236
Residue number B
562
Peptide name
Extracellular calcium-sensing receptor

Ligandability

Cysteine 236 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 562 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Extracellular calcium-sensing receptor between cysteines 568 and 585. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
5k5t
Structure name
crystal structure of the inactive form of human calcium-sensing receptor extracellular domain
Structure deposition date
2016-05-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41180
Residue number A
568
Residue number B
585
Peptide name
Extracellular calcium-sensing receptor

Ligandability

Cysteine 568 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 585 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Extracellular calcium-sensing receptor between cysteines 236 and 542. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
5k5s
Structure name
crystal structure of the active form of human calcium-sensing receptor extracellular domain
Structure deposition date
2016-05-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41180
Residue number A
236
Residue number B
542
Peptide name
Extracellular calcium-sensing receptor

Ligandability

Cysteine 236 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 542 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Extracellular calcium-sensing receptor between cysteines 691 and 694. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
7e6t
Structure name
structural insights into the activation of human calcium-sensing receptor
Structure deposition date
2021-02-24
Thiol separation (Å)
7
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
nan
Peptide accession
P41180
Residue number A
691
Residue number B
694
Peptide name
Extracellular calcium-sensing receptor

Ligandability

Cysteine 691 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 694 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Extracellular calcium-sensing receptor between cysteines 660 and 661. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
7m3e
Structure name
asymmetric activation of the calcium sensing receptor homodimer
Structure deposition date
2021-03-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
75
Minimum pKa ?
10
% buried
66
Peptide accession
P41180
Residue number A
660
Residue number B
661
Peptide name
Extracellular calcium-sensing receptor

Ligandability

Cysteine 660 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 661 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Extracellular calcium-sensing receptor between cysteines 546 and 582. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
5k5t
Structure name
crystal structure of the inactive form of human calcium-sensing receptor extracellular domain
Structure deposition date
2016-05-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41180
Residue number A
546
Residue number B
582
Peptide name
Extracellular calcium-sensing receptor

Ligandability

Cysteine 546 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 582 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Extracellular calcium-sensing receptor between cysteines 546 and 568. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
5k5t
Structure name
crystal structure of the inactive form of human calcium-sensing receptor extracellular domain
Structure deposition date
2016-05-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41180
Residue number A
546
Residue number B
568
Peptide name
Extracellular calcium-sensing receptor

Ligandability

Cysteine 546 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 568 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Extracellular calcium-sensing receptor between cysteines 582 and 598. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7dtw
Structure name
human calcium-sensing receptor in the inactive close-close conformation
Structure deposition date
2021-01-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41180
Residue number A
582
Residue number B
598
Peptide name
Extracellular calcium-sensing receptor

Ligandability

Cysteine 582 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 598 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Extracellular calcium-sensing receptor between cysteines 582 and 585. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
5k5s
Structure name
crystal structure of the active form of human calcium-sensing receptor extracellular domain
Structure deposition date
2016-05-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41180
Residue number A
582
Residue number B
585
Peptide name
Extracellular calcium-sensing receptor

Ligandability

Cysteine 582 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 585 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Extracellular calcium-sensing receptor between cysteines 660 and 694. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7e6u
Structure name
the complex of inactive casr and nb2d11
Structure deposition date
2021-02-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
76
Peptide accession
P41180
Residue number A
660
Residue number B
694
Peptide name
Extracellular calcium-sensing receptor

Ligandability

Cysteine 660 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 694 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 1 of Extracellular calcium-sensing receptor between cysteines 568 and 598. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
7sim
Structure name
structure of positive allosteric modulator-free active human calcium- sensing receptor
Structure deposition date
2021-10-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41180-1
Residue number A
568
Residue number B
598
Peptide name
Isoform 1 of Extracellular calcium-sensing receptor

Ligandability

Cysteine 568 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 598 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 1 of Extracellular calcium-sensing receptor between cysteines 565 and 582. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7sil
Structure name
structure of positive allosteric modulator-bound active human calcium- sensing receptor
Structure deposition date
2021-10-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41180-1
Residue number A
565
Residue number B
582
Peptide name
Isoform 1 of Extracellular calcium-sensing receptor

Ligandability

Cysteine 565 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 582 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Extracellular calcium-sensing receptor between cysteines 731 and 787. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7e6t
Structure name
structural insights into the activation of human calcium-sensing receptor
Structure deposition date
2021-02-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
56
Peptide accession
P41180
Residue number A
731
Residue number B
787
Peptide name
Extracellular calcium-sensing receptor

Ligandability

Cysteine 731 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 787 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Extracellular calcium-sensing receptor between cysteines 546 and 562. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7dtw
Structure name
human calcium-sensing receptor in the inactive close-close conformation
Structure deposition date
2021-01-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41180
Residue number A
546
Residue number B
562
Peptide name
Extracellular calcium-sensing receptor

Ligandability

Cysteine 546 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 562 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 1 of Extracellular calcium-sensing receptor between cysteines 660 and 691. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
7sil
Structure name
structure of positive allosteric modulator-bound active human calcium- sensing receptor
Structure deposition date
2021-10-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
10
% buried
70
Peptide accession
P41180-1
Residue number A
660
Residue number B
691
Peptide name
Isoform 1 of Extracellular calcium-sensing receptor

Ligandability

Cysteine 660 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 691 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 1 of Extracellular calcium-sensing receptor between cysteines 562 and 565. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
7sin
Structure name
structure of negative allosteric modulator-bound inactive human calcium-sensing receptor
Structure deposition date
2021-10-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41180-1
Residue number A
562
Residue number B
565
Peptide name
Isoform 1 of Extracellular calcium-sensing receptor

Ligandability

Cysteine 562 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 565 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 1 of Extracellular calcium-sensing receptor between cysteines 694 and 731. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7sim
Structure name
structure of positive allosteric modulator-free active human calcium- sensing receptor
Structure deposition date
2021-10-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
10
% buried
70
Peptide accession
P41180-1
Residue number A
694
Residue number B
731
Peptide name
Isoform 1 of Extracellular calcium-sensing receptor

Ligandability

Cysteine 694 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 731 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Extracellular calcium-sensing receptor between cysteines 661 and 694. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
7m3e
Structure name
asymmetric activation of the calcium sensing receptor homodimer
Structure deposition date
2021-03-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
81
Minimum pKa ?
9
% buried
88
Peptide accession
P41180
Residue number A
661
Residue number B
694
Peptide name
Extracellular calcium-sensing receptor

Ligandability

Cysteine 661 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 694 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 1 of Extracellular calcium-sensing receptor between cysteines 691 and 787. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
7sim
Structure name
structure of positive allosteric modulator-free active human calcium- sensing receptor
Structure deposition date
2021-10-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
100
Peptide accession
P41180-1
Residue number A
691
Residue number B
787
Peptide name
Isoform 1 of Extracellular calcium-sensing receptor

Ligandability

Cysteine 691 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 787 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 1 of Extracellular calcium-sensing receptor between cysteines 694 and 787. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
7sin
Structure name
structure of negative allosteric modulator-bound inactive human calcium-sensing receptor
Structure deposition date
2021-10-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
100
Peptide accession
P41180-1
Residue number A
694
Residue number B
787
Peptide name
Isoform 1 of Extracellular calcium-sensing receptor

Ligandability

Cysteine 694 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 787 of Isoform 1 of Extracellular calcium-sensing receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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