a tool for identifying drug-targetable redox-active disulphides

Aquaporin-2

Intramolecular

Cysteine 75 and cysteine 79

A redox-regulated disulphide may form within Aquaporin-2 between cysteines 75 and 79.

Details

Redox score ?

78

PDB code

Structure name

x-ray structure of human aquaporin 2

Structure deposition date

2013-10-29

Thiol separation (Å)

4

Half-sphere exposure sum ?

66

Minimum pK_a ?

7

% buried

67

Peptide accession

Residue number A

75

Residue number B

79

Peptide name

Aquaporin-2

Ligandability

Cysteine 75 of Aquaporin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 79 of Aquaporin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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