ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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B-cell lymphoma 6 protein

Intermolecular
Cysteine 8 and cysteine 8
Intramolecular
Cysteine 604 and cysteine 607
Cysteine 632 and cysteine 635
Cysteine 576 and cysteine 579
Cysteine 548 and cysteine 551
Cysteine 523 and cysteine 525
A redox-regulated disulphide may form between two units of B-cell lymphoma 6 protein at cysteines 8 and 8 (131 and 131 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
4u2m
Structure name
crystal structure of a complex of the miz1- and bcl6 poz domains
Structure deposition date
2014-07-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
67
Minimum pKa ?
9
% buried
56
Peptide A name
B-cell lymphoma 6 protein
Peptide B name
B-cell lymphoma 6 protein
Peptide A accession
P41182
Peptide B accession
P41182
Peptide A residue number
8
Peptide B residue number
8

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within B-cell lymphoma 6 protein between cysteines 604 and 607 (14 and 17 respectively in this structure).

Details

Redox score ?
89
PDB code
2en2
Structure name
solution structure of the c2h2 type zinc finger (region 598-626) of human b-cell lymphoma 6 protein
Structure deposition date
2007-03-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
38
Minimum pKa ?
6
% buried
0
Peptide accession
P41182
Residue number A
604
Residue number B
607
Peptide name
B-cell lymphoma 6 protein

Ligandability

Cysteine 604 of B-cell lymphoma 6 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 607 of B-cell lymphoma 6 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within B-cell lymphoma 6 protein between cysteines 632 and 635 (14 and 17 respectively in this structure).

Details

Redox score ?
89
PDB code
2eos
Structure name
solution structure of the c2h2 type zinc finger (region 626-654) of human b-cell lymphoma 6 protein
Structure deposition date
2007-03-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
41
Minimum pKa ?
5
% buried
0
Peptide accession
P41182
Residue number A
632
Residue number B
635
Peptide name
B-cell lymphoma 6 protein

Ligandability

Cysteine 632 of B-cell lymphoma 6 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 635 of B-cell lymphoma 6 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within B-cell lymphoma 6 protein between cysteines 576 and 579 (48 and 51 respectively in this structure).

Details

Redox score ?
86
PDB code
2lce
Structure name
chemical shift assignment of hr4436b from homo sapiens, northeast structural genomics consortium
Structure deposition date
2011-04-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
34
Minimum pKa ?
7
% buried
0
Peptide accession
P41182
Residue number A
576
Residue number B
579
Peptide name
B-cell lymphoma 6 protein

Ligandability

Cysteine 576 of B-cell lymphoma 6 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 579 of B-cell lymphoma 6 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within B-cell lymphoma 6 protein between cysteines 548 and 551 (20 and 23 respectively in this structure).

Details

Redox score ?
84
PDB code
2lce
Structure name
chemical shift assignment of hr4436b from homo sapiens, northeast structural genomics consortium
Structure deposition date
2011-04-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
37
Minimum pKa ?
7
% buried
0
Peptide accession
P41182
Residue number A
548
Residue number B
551
Peptide name
B-cell lymphoma 6 protein

Ligandability

Cysteine 548 of B-cell lymphoma 6 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 551 of B-cell lymphoma 6 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within B-cell lymphoma 6 protein between cysteines 523 and 525 (24 and 26 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
4u2m
Structure name
crystal structure of a complex of the miz1- and bcl6 poz domains
Structure deposition date
2014-07-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
52
Minimum pKa ?
12
% buried
68
Peptide accession
P41182
Residue number A
523
Residue number B
525
Peptide name
B-cell lymphoma 6 protein

Ligandability

Cysteine 523 of B-cell lymphoma 6 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 525 of B-cell lymphoma 6 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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