ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Eukaryotic translation initiation factor 2D

Intramolecular
Cysteine 300 and cysteine 301
Cysteine 442 and cysteine 464
Cysteine 440 and cysteine 442
A redox-regulated disulphide may form within Eukaryotic translation initiation factor 2D between cysteines 300 and 301.

Details

Redox score ?
65
PDB code
5oa3
Structure name
human 40s-eif2d-re-initiation complex
Structure deposition date
2017-06-20
Thiol separation (Å)
7
Half-sphere exposure sum ?
19
Minimum pKa ?
9
% buried
0
Peptide accession
P41214
Residue number A
300
Residue number B
301
Peptide name
Eukaryotic translation initiation factor 2D

Ligandability

Cysteine 300 of Eukaryotic translation initiation factor 2D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 301 of Eukaryotic translation initiation factor 2D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Eukaryotic translation initiation factor 2D between cysteines 442 and 464. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
5oa9
Structure name
human translation re-initiation complex containing eif2d
Structure deposition date
2017-06-21
Thiol separation (Å)
6
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
78
Peptide accession
P41214
Residue number A
442
Residue number B
464
Peptide name
Eukaryotic translation initiation factor 2D

Ligandability

Cysteine 442 of Eukaryotic translation initiation factor 2D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 464 of Eukaryotic translation initiation factor 2D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Eukaryotic translation initiation factor 2D between cysteines 440 and 442. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
5oa9
Structure name
human translation re-initiation complex containing eif2d
Structure deposition date
2017-06-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
42
Peptide accession
P41214
Residue number A
440
Residue number B
442
Peptide name
Eukaryotic translation initiation factor 2D

Ligandability

Cysteine 440 of Eukaryotic translation initiation factor 2D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 442 of Eukaryotic translation initiation factor 2D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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