Mitogen-activated protein kinase kinase kinase 8
Intermolecular
Cysteine 222 and cysteine 222
4y85 A 222 C 222
A redox-regulated disulphide may form between two units of Mitogen-activated protein kinase kinase kinase 8 at cysteines 222 and 222.
Details
Redox score ?
78
PDB code
4y85
Structure name
crystal structure of cot kinase domain in complex with 5-(5-(1h-indol- 3-yl)-1h-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amine
Structure deposition date
2015-02-16
Thiol separation (Å)
3
Half-sphere exposure sum ?
66
Minimum pKa ?
8
% buried
75
Peptide A name
Mitogen-activated protein kinase kinase kinase 8
Peptide B name
Mitogen-activated protein kinase kinase kinase 8
Peptide A accession
P41279
Peptide B accession
P41279
Peptide A residue number
222
Peptide B residue number
222
Ligandability
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