ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Vasoactive intestinal polypeptide receptor 2

Intramolecular
Cysteine 75 and cysteine 109
Cysteine 52 and cysteine 93
Cysteine 202 and cysteine 271
Cysteine 38 and cysteine 61
Cysteine 25 and cysteine 192
Cysteine 25 and cysteine 271
Cysteine 25 and cysteine 202
Cysteine 149 and cysteine 376
A redox-regulated disulphide may form within Vasoactive intestinal polypeptide receptor 2 between cysteines 75 and 109.

Details

Redox score ?
86
PDB code
2x57
Structure name
crystal structure of the extracellular domain of human vasoactive intestinal polypeptide receptor 2
Structure deposition date
2010-02-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41587
Residue number A
75
Residue number B
109
Peptide name
Vasoactive intestinal polypeptide receptor 2

Ligandability

Cysteine 75 of Vasoactive intestinal polypeptide receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of Vasoactive intestinal polypeptide receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasoactive intestinal polypeptide receptor 2 between cysteines 52 and 93.

Details

Redox score ?
86
PDB code
2x57
Structure name
crystal structure of the extracellular domain of human vasoactive intestinal polypeptide receptor 2
Structure deposition date
2010-02-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41587
Residue number A
52
Residue number B
93
Peptide name
Vasoactive intestinal polypeptide receptor 2

Ligandability

Cysteine 52 of Vasoactive intestinal polypeptide receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 93 of Vasoactive intestinal polypeptide receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasoactive intestinal polypeptide receptor 2 between cysteines 202 and 271.

Details

Redox score ?
86
PDB code
7wbj
Structure name
cryo-em structure of n-terminal modified human vasoactive intestinal polypeptide receptor 2 (vip2r) in complex with pacap27 and gs
Structure deposition date
2021-12-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41587
Residue number A
202
Residue number B
271
Peptide name
Vasoactive intestinal polypeptide receptor 2

Ligandability

Cysteine 202 of Vasoactive intestinal polypeptide receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 271 of Vasoactive intestinal polypeptide receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasoactive intestinal polypeptide receptor 2 between cysteines 38 and 61.

Details

Redox score ?
80
PDB code
2x57
Structure name
crystal structure of the extracellular domain of human vasoactive intestinal polypeptide receptor 2
Structure deposition date
2010-02-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41587
Residue number A
38
Residue number B
61
Peptide name
Vasoactive intestinal polypeptide receptor 2

Ligandability

Cysteine 38 of Vasoactive intestinal polypeptide receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 61 of Vasoactive intestinal polypeptide receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasoactive intestinal polypeptide receptor 2 between cysteines 25 and 192. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
7vqx
Structure name
cryo-em structure of human vasoactive intestinal polypeptide receptor 2 (vip2r) in complex with pacap27 and gs
Structure deposition date
2021-10-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
58
Peptide accession
P41587
Residue number A
25
Residue number B
192
Peptide name
Vasoactive intestinal polypeptide receptor 2

Ligandability

Cysteine 25 of Vasoactive intestinal polypeptide receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 192 of Vasoactive intestinal polypeptide receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasoactive intestinal polypeptide receptor 2 between cysteines 25 and 271. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
7vqx
Structure name
cryo-em structure of human vasoactive intestinal polypeptide receptor 2 (vip2r) in complex with pacap27 and gs
Structure deposition date
2021-10-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
11
% buried
nan
Peptide accession
P41587
Residue number A
25
Residue number B
271
Peptide name
Vasoactive intestinal polypeptide receptor 2

Ligandability

Cysteine 25 of Vasoactive intestinal polypeptide receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 271 of Vasoactive intestinal polypeptide receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasoactive intestinal polypeptide receptor 2 between cysteines 25 and 202. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
7vqx
Structure name
cryo-em structure of human vasoactive intestinal polypeptide receptor 2 (vip2r) in complex with pacap27 and gs
Structure deposition date
2021-10-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
nan
Peptide accession
P41587
Residue number A
25
Residue number B
202
Peptide name
Vasoactive intestinal polypeptide receptor 2

Ligandability

Cysteine 25 of Vasoactive intestinal polypeptide receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 202 of Vasoactive intestinal polypeptide receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Vasoactive intestinal polypeptide receptor 2 between cysteines 149 and 376. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
7vqx
Structure name
cryo-em structure of human vasoactive intestinal polypeptide receptor 2 (vip2r) in complex with pacap27 and gs
Structure deposition date
2021-10-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
44
Peptide accession
P41587
Residue number A
149
Residue number B
376
Peptide name
Vasoactive intestinal polypeptide receptor 2

Ligandability

Cysteine 149 of Vasoactive intestinal polypeptide receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 376 of Vasoactive intestinal polypeptide receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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