ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

5-hydroxytryptamine receptor 2B

Intramolecular
Cysteine 350 and cysteine 353
Cysteine 128 and cysteine 207
A redox-regulated disulphide may form within 5-hydroxytryptamine receptor 2B between cysteines 350 and 353.

Details

Redox score ?
89
PDB code
5tud
Structure name
structural insights into the extracellular recognition of the human serotonin 2b receptor by an antibody
Structure deposition date
2016-11-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
31
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41595
Residue number A
350
Residue number B
353
Peptide name
5-hydroxytryptamine receptor 2B

Ligandability

Cysteine 350 of 5-hydroxytryptamine receptor 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 353 of 5-hydroxytryptamine receptor 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 5-hydroxytryptamine receptor 2B between cysteines 128 and 207.

Details

Redox score ?
85
PDB code
6dry
Structure name
structural determinants of activation and biased agonism at the 5-ht2b receptor
Structure deposition date
2018-06-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41595
Residue number A
128
Residue number B
207
Peptide name
5-hydroxytryptamine receptor 2B

Ligandability

Cysteine 128 of 5-hydroxytryptamine receptor 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 207 of 5-hydroxytryptamine receptor 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: