C-C chemokine receptor type 2
Intermolecular
Cysteine 32 and cysteine 34 of C-C motif chemokine 2
Cysteine 75 and cysteine 351 of Guanine nucleotide-binding protein G(i) subunit alpha-1
Intramolecular
Cysteine 113 and cysteine 190
Cysteine 32 and cysteine 277
Cysteine 113 and cysteine 181
Cysteine 181 and cysteine 190
Cysteine 70 and cysteine 75
Cysteine 298 and cysteine 299
Cysteine 332 and cysteine 332
Cysteine 75 and cysteine 332
More...Cysteine 75 and cysteine 1009
Cysteine 1009 and cysteine 332
7xa3 R 32 L 11
A redox-regulated disulphide may form between cysteine 32 of C-C chemokine receptor type 2 and cysteine 34 of C-C motif chemokine 2 (32 and 11 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7xa3
Structure name
cryo-em structure of the ccl2 bound ccr2-gi complex
Structure deposition date
2022-03-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide A name
C-C chemokine receptor type 2
Peptide B name
C-C motif chemokine 2
Peptide A accession
P41597
Peptide B accession
P13500
Peptide A residue number
32
Peptide B residue number
34
Ligandability
Cysteine 32 of C-C chemokine receptor type 2
Cysteine 34 of C-C motif chemokine 2
7xa3 R 75 A 351
A redox-regulated disulphide may form between cysteine 75 of C-C chemokine receptor type 2 and cysteine 351 of Guanine nucleotide-binding protein G(i) subunit alpha-1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
7xa3
Structure name
cryo-em structure of the ccl2 bound ccr2-gi complex
Structure deposition date
2022-03-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
84
Peptide A name
C-C chemokine receptor type 2
Peptide B name
Guanine nucleotide-binding protein G(i) subunit alpha-1
Peptide A accession
P41597
Peptide B accession
P63096
Peptide A residue number
75
Peptide B residue number
351
Ligandability
Cysteine 75 of C-C chemokine receptor type 2
Cysteine 351 of Guanine nucleotide-binding protein G(i) subunit alpha-1
6gpx B 113 B 190
A redox-regulated disulphide may form within C-C chemokine receptor type 2 between cysteines 113 and 190.
Details
Redox score ?
85
PDB code
6gpx
Structure name
crystal structure of ccr2a in complex with mk-0812
Structure deposition date
2018-06-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41597
Residue number A
113
Residue number B
190
Peptide name
C-C chemokine receptor type 2
Ligandability
Cysteine 113 of C-C chemokine receptor type 2
Cysteine 190 of C-C chemokine receptor type 2
7xa3 R 32 R 277
A redox-regulated disulphide may form within C-C chemokine receptor type 2 between cysteines 32 and 277.
Details
Redox score ?
84
PDB code
7xa3
Structure name
cryo-em structure of the ccl2 bound ccr2-gi complex
Structure deposition date
2022-03-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
P41597
Residue number A
32
Residue number B
277
Peptide name
C-C chemokine receptor type 2
Ligandability
Cysteine 32 of C-C chemokine receptor type 2
Cysteine 277 of C-C chemokine receptor type 2
6gpx A 113 A 181
A redox-regulated disulphide may form within C-C chemokine receptor type 2 between cysteines 113 and 181. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
60
PDB code
6gpx
Structure name
crystal structure of ccr2a in complex with mk-0812
Structure deposition date
2018-06-07
Thiol separation (Å)
6
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
nan
Peptide accession
P41597
Residue number A
113
Residue number B
181
Peptide name
C-C chemokine receptor type 2
Ligandability
Cysteine 113 of C-C chemokine receptor type 2
Cysteine 181 of C-C chemokine receptor type 2
6gpx A 181 A 190
A redox-regulated disulphide may form within C-C chemokine receptor type 2 between cysteines 181 and 190. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
6gpx
Structure name
crystal structure of ccr2a in complex with mk-0812
Structure deposition date
2018-06-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
nan
Peptide accession
P41597
Residue number A
181
Residue number B
190
Peptide name
C-C chemokine receptor type 2
Ligandability
Cysteine 181 of C-C chemokine receptor type 2
Cysteine 190 of C-C chemokine receptor type 2
7xa3 R 70 R 75
A redox-regulated disulphide may form within C-C chemokine receptor type 2 between cysteines 70 and 75. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
7xa3
Structure name
cryo-em structure of the ccl2 bound ccr2-gi complex
Structure deposition date
2022-03-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
53
Minimum pKa ?
10
% buried
56
Peptide accession
P41597
Residue number A
70
Residue number B
75
Peptide name
C-C chemokine receptor type 2
Ligandability
Cysteine 70 of C-C chemokine receptor type 2
Cysteine 75 of C-C chemokine receptor type 2
5t1a A 298 A 299
A redox-regulated disulphide may form within C-C chemokine receptor type 2 between cysteines 298 and 299. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
5t1a
Structure name
structure of cc chemokine receptor 2 with orthosteric and allosteric antagonists
Structure deposition date
2016-08-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
91
Minimum pKa ?
11
% buried
84
Peptide accession
P41597
Residue number A
298
Residue number B
299
Peptide name
C-C chemokine receptor type 2
Ligandability
Cysteine 298 of C-C chemokine receptor type 2
Cysteine 299 of C-C chemokine receptor type 2
6gpx A 270 A 273
A redox-regulated disulphide may form within C-C chemokine receptor type 2 between cysteines 332 and 332 (270 and 273 respectively in this structure).
Details
Redox score ?
nan
PDB code
6gpx
Structure name
crystal structure of ccr2a in complex with mk-0812
Structure deposition date
2018-06-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
8
% buried
4
Peptide accession
P41597
Residue number A
332
Residue number B
332
Peptide name
C-C chemokine receptor type 2
Ligandability
Cysteine 332 of C-C chemokine receptor type 2
Cysteine 332 of C-C chemokine receptor type 2
Uncertain whether structure cysteine 270 has been assigned to correct residue.
Uncertain whether structure cysteine 273 has been assigned to correct residue.
6gps A 1006 A 1042
A redox-regulated disulphide may form within C-C chemokine receptor type 2 between cysteines 75 and 332 (1006 and 1042 respectively in this structure).
Details
Redox score ?
nan
PDB code
6gps
Structure name
crystal structure of ccr2a in complex with mk-0812
Structure deposition date
2018-06-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
41
Minimum pKa ?
6
% buried
0
Peptide accession
P41597
Residue number A
75
Residue number B
332
Peptide name
C-C chemokine receptor type 2
Ligandability
Cysteine 75 of C-C chemokine receptor type 2
Cysteine 332 of C-C chemokine receptor type 2
Uncertain whether structure cysteine 1006 has been assigned to correct residue.
Uncertain whether structure cysteine 1042 has been assigned to correct residue.
6gps A 1006 A 1009
A redox-regulated disulphide may form within C-C chemokine receptor type 2 between cysteines 75 and 1009 (1006 and 1009 respectively in this structure).
Details
Redox score ?
nan
PDB code
6gps
Structure name
crystal structure of ccr2a in complex with mk-0812
Structure deposition date
2018-06-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
42
Minimum pKa ?
6
% buried
0
Peptide accession
P41597
Residue number A
75
Residue number B
1009
Peptide name
C-C chemokine receptor type 2
Ligandability
Cysteine 75 of C-C chemokine receptor type 2
Cysteine 1009 of C-C chemokine receptor type 2
Uncertain whether structure cysteine 1006 has been assigned to correct residue.
Cysteine 1009 in protein B could not be asigned to a Uniprot residue.
6gps A 1009 A 1042
A redox-regulated disulphide may form within C-C chemokine receptor type 2 between cysteines 1009 and 332 (1009 and 1042 respectively in this structure).
Details
Redox score ?
nan
PDB code
6gps
Structure name
crystal structure of ccr2a in complex with mk-0812
Structure deposition date
2018-06-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
31
Minimum pKa ?
9
% buried
0
Peptide accession
P41597
Residue number A
1009
Residue number B
332
Peptide name
C-C chemokine receptor type 2
Ligandability
Cysteine 1009 of C-C chemokine receptor type 2
Cysteine 332 of C-C chemokine receptor type 2
Cysteine 1009 in protein A could not be asigned to a Uniprot residue.
Uncertain whether structure cysteine 1042 has been assigned to correct residue.
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