a tool for identifying drug-targetable redox-active disulphides

Protein kinase C iota type

Intramolecular

Cysteine 399 and cysteine 413 L

A redox-regulated disulphide may form within Protein kinase C iota type between cysteines 399 and 413 (390 and 404 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

32

PDB code

Structure name

structure of pkc in complex with a substrate peptide from par-3

Structure deposition date

2012-01-17

Thiol separation (Å)

10

Half-sphere exposure sum ?

73

Minimum pK_a ?

11

% buried

86

Peptide accession

Residue number A

399

Residue number B

413

Peptide name

Protein kinase C iota type

Ligandability

Cysteine 399 of Protein kinase C iota type

Not ligandable in the dataset of Yang et al.

Ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 413 of Protein kinase C iota type

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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