a tool for identifying drug-targetable redox-active disulphides

Lamina-associated polypeptide 2, isoforms alpha/zeta

Intermolecular

Cysteine 560 and cysteine 560 L

A redox-regulated disulphide may form between two units of Lamina-associated polypeptide 2, isoforms alpha/zeta at cysteines 560 and 560. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

40

PDB code

Structure name

the dimerization domain of lap2alpha

Structure deposition date

2007-05-20

Thiol separation (Å)

9

Half-sphere exposure sum ?

50

Minimum pK_a ?

11

% buried

68

Peptide A name

Lamina-associated polypeptide 2, isoforms alpha/zeta

Peptide B name

Lamina-associated polypeptide 2, isoforms alpha/zeta

Peptide A accession

Peptide B accession

Peptide A residue number

560

Peptide B residue number

560

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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