a tool for identifying drug-targetable redox-active disulphides

Signal transducer and activator of transcription 1-alpha/beta

Intramolecular

Cysteine 247 and cysteine 324

A redox-regulated disulphide may form within Signal transducer and activator of transcription 1-alpha/beta between cysteines 247 and 324. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

39

PDB code

Structure name

vaccinia virus protein 018 in complex with stat1

Structure deposition date

2021-03-12

Thiol separation (Å)

8

Half-sphere exposure sum ?

72

Minimum pK_a ?

11

% buried

84

Peptide accession

Residue number A

247

Residue number B

324

Peptide name

Signal transducer and activator of transcription 1-alpha/beta

Ligandability

Cysteine 247 of Signal transducer and activator of transcription 1-alpha/beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 324 of Signal transducer and activator of transcription 1-alpha/beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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