ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Signal transducer and activator of transcription 6

Intramolecular
Cysteine 228 and cysteine 272
Cysteine 371 and cysteine 384
Cysteine 355 and cysteine 356
A redox-regulated disulphide may form within Signal transducer and activator of transcription 6 between cysteines 228 and 272.

Details

Redox score ?
74
PDB code
5d39
Structure name
transcription factor-dna complex
Structure deposition date
2015-08-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
8
% buried
91
Peptide accession
P42226
Residue number A
228
Residue number B
272
Peptide name
Signal transducer and activator of transcription 6

Ligandability

Cysteine 228 of Signal transducer and activator of transcription 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 272 of Signal transducer and activator of transcription 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Signal transducer and activator of transcription 6 between cysteines 371 and 384. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
5d39
Structure name
transcription factor-dna complex
Structure deposition date
2015-08-06
Thiol separation (Å)
8
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
50
Peptide accession
P42226
Residue number A
371
Residue number B
384
Peptide name
Signal transducer and activator of transcription 6

Ligandability

Cysteine 371 of Signal transducer and activator of transcription 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 384 of Signal transducer and activator of transcription 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Signal transducer and activator of transcription 6 between cysteines 355 and 356. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
5d39
Structure name
transcription factor-dna complex
Structure deposition date
2015-08-06
Thiol separation (Å)
8
Half-sphere exposure sum ?
63
Minimum pKa ?
9
% buried
40
Peptide accession
P42226
Residue number A
355
Residue number B
356
Peptide name
Signal transducer and activator of transcription 6

Ligandability

Cysteine 355 of Signal transducer and activator of transcription 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 356 of Signal transducer and activator of transcription 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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