Exosome RNA helicase MTR4
Intramolecular
Cysteine 110 and cysteine 150
Cysteine 297 and cysteine 304
Cysteine 150 and cysteine 170
Cysteine 911 and cysteine 996
Cysteine 150 and cysteine 304
6ieh B 110 B 150
A redox-regulated disulphide may form within Exosome RNA helicase MTR4 between cysteines 110 and 150. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
6ieh
Structure name
crystal structures of the hmtr4-nrde2 complex
Structure deposition date
2018-09-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
73
Peptide accession
P42285
Residue number A
110
Residue number B
150
Peptide name
Exosome RNA helicase MTR4
Ligandability
Cysteine 110 of Exosome RNA helicase MTR4
Cysteine 150 of Exosome RNA helicase MTR4
6ieg B 297 B 304
A redox-regulated disulphide may form within Exosome RNA helicase MTR4 between cysteines 297 and 304. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
6ieg
Structure name
crystal structure of human mtr4
Structure deposition date
2018-09-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
12
% buried
82
Peptide accession
P42285
Residue number A
297
Residue number B
304
Peptide name
Exosome RNA helicase MTR4
Ligandability
Cysteine 297 of Exosome RNA helicase MTR4
Cysteine 304 of Exosome RNA helicase MTR4
6ieh B 150 B 170
A redox-regulated disulphide may form within Exosome RNA helicase MTR4 between cysteines 150 and 170. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
6ieh
Structure name
crystal structures of the hmtr4-nrde2 complex
Structure deposition date
2018-09-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
100
Peptide accession
P42285
Residue number A
150
Residue number B
170
Peptide name
Exosome RNA helicase MTR4
Ligandability
Cysteine 150 of Exosome RNA helicase MTR4
Cysteine 170 of Exosome RNA helicase MTR4
6c90 A 911 A 996
A redox-regulated disulphide may form within Exosome RNA helicase MTR4 between cysteines 911 and 996. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
6c90
Structure name
human mtr4 helicase in complex with zcchc8-ctd
Structure deposition date
2018-01-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
12
% buried
100
Peptide accession
P42285
Residue number A
911
Residue number B
996
Peptide name
Exosome RNA helicase MTR4
Ligandability
Cysteine 911 of Exosome RNA helicase MTR4
Cysteine 996 of Exosome RNA helicase MTR4
6c90 A 150 A 304
A redox-regulated disulphide may form within Exosome RNA helicase MTR4 between cysteines 150 and 304. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
31
PDB code
6c90
Structure name
human mtr4 helicase in complex with zcchc8-ctd
Structure deposition date
2018-01-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
13
% buried
100
Peptide accession
P42285
Residue number A
150
Residue number B
304
Peptide name
Exosome RNA helicase MTR4
Ligandability
Cysteine 150 of Exosome RNA helicase MTR4
Cysteine 304 of Exosome RNA helicase MTR4
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