ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Rho GTPase-activating protein 25

Intramolecular
Cysteine 89 and cysteine 95
A redox-regulated disulphide may form within Rho GTPase-activating protein 25 between cysteines 89 and 95 (50 and 56 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
1v89
Structure name
solution structure of the pleckstrin homology domain of human kiaa0053 protein
Structure deposition date
2003-12-29
Thiol separation (Å)
10
Half-sphere exposure sum ?
54
Minimum pKa ?
9
% buried
23
Peptide accession
P42331
Residue number A
89
Residue number B
95
Peptide name
Rho GTPase-activating protein 25

Ligandability

Cysteine 89 of Rho GTPase-activating protein 25

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 95 of Rho GTPase-activating protein 25

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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