ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Phosphatidylinositol 4-kinase alpha

Intermolecular
Cysteine 1611 and cysteine 423 of Tetratricopeptide repeat protein 7B
Intramolecular
Cysteine 1855 and cysteine 1893
A redox-regulated disulphide may form between cysteine 1611 of Phosphatidylinositol 4-kinase alpha and cysteine 423 of Tetratricopeptide repeat protein 7B. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6bq1
Structure name
human pi4kiiia lipid kinase complex
Structure deposition date
2017-11-27
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
96
Peptide A name
Phosphatidylinositol 4-kinase alpha
Peptide B name
Tetratricopeptide repeat protein 7B
Peptide A accession
P42356
Peptide B accession
Q86TV6
Peptide A residue number
1611
Peptide B residue number
423

Ligandability

Cysteine 1611 of Phosphatidylinositol 4-kinase alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 423 of Tetratricopeptide repeat protein 7B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phosphatidylinositol 4-kinase alpha between cysteines 1855 and 1893. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
6bq1
Structure name
human pi4kiiia lipid kinase complex
Structure deposition date
2017-11-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
83
Minimum pKa ?
11
% buried
83
Peptide accession
P42356
Residue number A
1855
Residue number B
1893
Peptide name
Phosphatidylinositol 4-kinase alpha

Ligandability

Cysteine 1855 of Phosphatidylinositol 4-kinase alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1893 of Phosphatidylinositol 4-kinase alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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