a tool for identifying drug-targetable redox-active disulphides

Epidermal growth factor receptor substrate 15

Intramolecular

Cysteine 269 and cysteine 274

A redox-regulated disulphide may form within Epidermal growth factor receptor substrate 15 between cysteines 269 and 274 (61 and 66 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

39

PDB code

Structure name

structure of the third eps15 homology domain of human eps15

Structure deposition date

1999-07-14

Thiol separation (Å)

9

Half-sphere exposure sum ?

63

Minimum pK_a ?

9

% buried

50

Peptide accession

Residue number A

269

Residue number B

274

Peptide name

Epidermal growth factor receptor substrate 15

Ligandability

Cysteine 269 of Epidermal growth factor receptor substrate 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 274 of Epidermal growth factor receptor substrate 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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