ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Dipeptidyl aminopeptidase-like protein 6

Intermolecular
Cysteine 107 and cysteine 236 of Potassium voltage-gated channel subfamily D member 2
Intramolecular
Cysteine 411 and cysteine 418
Cysteine 536 and cysteine 554
Cysteine 527 and cysteine 530
Cysteine 735 and cysteine 846
A redox-regulated disulphide may form between cysteine 107 of Dipeptidyl aminopeptidase-like protein 6 and cysteine 236 of Potassium voltage-gated channel subfamily D member 2 (45 and 236 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
7e8h
Structure name
cryoem structure of human kv4
Structure deposition date
2021-03-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
47
Peptide A name
Dipeptidyl aminopeptidase-like protein 6
Peptide B name
Potassium voltage-gated channel subfamily D member 2
Peptide A accession
P42658
Peptide B accession
Q9NZV8
Peptide A residue number
107
Peptide B residue number
236

Ligandability

Cysteine 107 of Dipeptidyl aminopeptidase-like protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 236 of Potassium voltage-gated channel subfamily D member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dipeptidyl aminopeptidase-like protein 6 between cysteines 411 and 418 (349 and 356 respectively in this structure).

Details

Redox score ?
87
PDB code
7e8h
Structure name
cryoem structure of human kv4
Structure deposition date
2021-03-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P42658
Residue number A
411
Residue number B
418
Peptide name
Dipeptidyl aminopeptidase-like protein 6

Ligandability

Cysteine 411 of Dipeptidyl aminopeptidase-like protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 418 of Dipeptidyl aminopeptidase-like protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dipeptidyl aminopeptidase-like protein 6 between cysteines 536 and 554 (474 and 492 respectively in this structure).

Details

Redox score ?
84
PDB code
7e89
Structure name
cryoem structure of human kv4
Structure deposition date
2021-03-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P42658
Residue number A
536
Residue number B
554
Peptide name
Dipeptidyl aminopeptidase-like protein 6

Ligandability

Cysteine 536 of Dipeptidyl aminopeptidase-like protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 554 of Dipeptidyl aminopeptidase-like protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dipeptidyl aminopeptidase-like protein 6 between cysteines 527 and 530 (465 and 468 respectively in this structure).

Details

Redox score ?
83
PDB code
7e8g
Structure name
cryoem structure of human kv4
Structure deposition date
2021-03-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P42658
Residue number A
527
Residue number B
530
Peptide name
Dipeptidyl aminopeptidase-like protein 6

Ligandability

Cysteine 527 of Dipeptidyl aminopeptidase-like protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 530 of Dipeptidyl aminopeptidase-like protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dipeptidyl aminopeptidase-like protein 6 between cysteines 735 and 846 (673 and 784 respectively in this structure).

Details

Redox score ?
80
PDB code
7e8g
Structure name
cryoem structure of human kv4
Structure deposition date
2021-03-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P42658
Residue number A
735
Residue number B
846
Peptide name
Dipeptidyl aminopeptidase-like protein 6

Ligandability

Cysteine 735 of Dipeptidyl aminopeptidase-like protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 846 of Dipeptidyl aminopeptidase-like protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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