40S ribosomal protein S27
Intermolecular
Cysteine 443 of Eukaryotic translation initiation factor 3 subunit C and cysteine 59
Intramolecular
Cysteine 56 and cysteine 59
Cysteine 37 and cysteine 56
Cysteine 40 and cysteine 59
Cysteine 40 and cysteine 56
Cysteine 37 and cysteine 40
Cysteine 37 and cysteine 59
Cysteine 37 and cysteine 77 L
Cysteine 59 and cysteine 77 L
Cysteine 40 and cysteine 77 L
More...Cysteine 64 and cysteine 77 L
Cysteine 56 and cysteine 77 L
6ybd y 443 H 59
A redox-regulated disulphide may form between cysteine 443 of Eukaryotic translation initiation factor 3 subunit C and cysteine 59 of 40S ribosomal protein S27.
Details
Redox score ?
70
PDB code
6ybd
Structure name
structure of a human 48s translational initiation complex - eif3
Structure deposition date
2020-03-16
Thiol separation (Å)
5
Half-sphere exposure sum ?
69
Minimum pKa ?
6
% buried
68
Peptide A name
Eukaryotic translation initiation factor 3 subunit C
Peptide B name
40S ribosomal protein S27
Peptide A accession
Q99613
Peptide B accession
P42677
Peptide A residue number
443
Peptide B residue number
59
Ligandability
Cysteine 443 of Eukaryotic translation initiation factor 3 subunit C
Cysteine 59 of 40S ribosomal protein S27
7tql b 56 b 59
A redox-regulated disulphide may form within 40S ribosomal protein S27 between cysteines 56 and 59.
Details
Redox score ?
86
PDB code
7tql
Structure name
cryoem structure of the human 40s small ribosomal subunit in complex with translation initiation factors eif1a and eif5b
Structure deposition date
2022-01-26
Thiol separation (Å)
3
Half-sphere exposure sum ?
44
Minimum pKa ?
8
% buried
0
Peptide accession
P42677
Residue number A
56
Residue number B
59
Peptide name
40S ribosomal protein S27
Ligandability
Cysteine 56 of 40S ribosomal protein S27
Cysteine 59 of 40S ribosomal protein S27
7tql b 37 b 56
A redox-regulated disulphide may form within 40S ribosomal protein S27 between cysteines 37 and 56.
Details
Redox score ?
82
PDB code
7tql
Structure name
cryoem structure of the human 40s small ribosomal subunit in complex with translation initiation factors eif1a and eif5b
Structure deposition date
2022-01-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
8
% buried
0
Peptide accession
P42677
Residue number A
37
Residue number B
56
Peptide name
40S ribosomal protein S27
Ligandability
Cysteine 37 of 40S ribosomal protein S27
Cysteine 56 of 40S ribosomal protein S27
7wtv b 40 b 59
A redox-regulated disulphide may form within 40S ribosomal protein S27 between cysteines 40 and 59.
Details
Redox score ?
78
PDB code
7wtv
Structure name
cryo-em structure of a human pre-40s ribosomal subunit - state rrp12- a2
Structure deposition date
2022-02-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
37
Minimum pKa ?
8
% buried
0
Peptide accession
P42677
Residue number A
40
Residue number B
59
Peptide name
40S ribosomal protein S27
Ligandability
Cysteine 40 of 40S ribosomal protein S27
Cysteine 59 of 40S ribosomal protein S27
7wtw b 40 b 56
A redox-regulated disulphide may form within 40S ribosomal protein S27 between cysteines 40 and 56.
Details
Redox score ?
73
PDB code
7wtw
Structure name
cryo-em structure of a human pre-40s ribosomal subunit - state rrp12- a3
Structure deposition date
2022-02-05
Thiol separation (Å)
6
Half-sphere exposure sum ?
46
Minimum pKa ?
7
% buried
0
Peptide accession
P42677
Residue number A
40
Residue number B
56
Peptide name
40S ribosomal protein S27
Ligandability
Cysteine 40 of 40S ribosomal protein S27
Cysteine 56 of 40S ribosomal protein S27
7wtv b 37 b 40
A redox-regulated disulphide may form within 40S ribosomal protein S27 between cysteines 37 and 40.
Details
Redox score ?
69
PDB code
7wtv
Structure name
cryo-em structure of a human pre-40s ribosomal subunit - state rrp12- a2
Structure deposition date
2022-02-05
Thiol separation (Å)
6
Half-sphere exposure sum ?
49
Minimum pKa ?
8
% buried
0
Peptide accession
P42677
Residue number A
37
Residue number B
40
Peptide name
40S ribosomal protein S27
Ligandability
Cysteine 37 of 40S ribosomal protein S27
Cysteine 40 of 40S ribosomal protein S27
7k5i b 37 b 59
A redox-regulated disulphide may form within 40S ribosomal protein S27 between cysteines 37 and 59.
Details
Redox score ?
67
PDB code
7k5i
Structure name
sars-cov-2 nsp1 in complex with human 40s ribosome
Structure deposition date
2020-09-16
Thiol separation (Å)
6
Half-sphere exposure sum ?
47
Minimum pKa ?
7
% buried
nan
Peptide accession
P42677
Residue number A
37
Residue number B
59
Peptide name
40S ribosomal protein S27
Ligandability
Cysteine 37 of 40S ribosomal protein S27
Cysteine 59 of 40S ribosomal protein S27
7wtw b 37 b 77
A redox-regulated disulphide may form within 40S ribosomal protein S27 between cysteines 37 and 77.
Details
Redox score ?
64
PDB code
7wtw
Structure name
cryo-em structure of a human pre-40s ribosomal subunit - state rrp12- a3
Structure deposition date
2022-02-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
54
Minimum pKa ?
8
% buried
14
Peptide accession
P42677
Residue number A
37
Residue number B
77
Peptide name
40S ribosomal protein S27
Ligandability
Cysteine 37 of 40S ribosomal protein S27
Cysteine 77 of 40S ribosomal protein S27
5flx b 59 b 77
A redox-regulated disulphide may form within 40S ribosomal protein S27 between cysteines 59 and 77.
Details
Redox score ?
61
PDB code
5flx
Structure name
mammalian 40s hcv-ires complex
Structure deposition date
2015-10-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
43
Minimum pKa ?
9
% buried
18
Peptide accession
P42677
Residue number A
59
Residue number B
77
Peptide name
40S ribosomal protein S27
Ligandability
Cysteine 59 of 40S ribosomal protein S27
Cysteine 77 of 40S ribosomal protein S27
7tql b 40 b 77
A redox-regulated disulphide may form within 40S ribosomal protein S27 between cysteines 40 and 77. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
7tql
Structure name
cryoem structure of the human 40s small ribosomal subunit in complex with translation initiation factors eif1a and eif5b
Structure deposition date
2022-01-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
43
Minimum pKa ?
9
% buried
6
Peptide accession
P42677
Residue number A
40
Residue number B
77
Peptide name
40S ribosomal protein S27
Ligandability
Cysteine 40 of 40S ribosomal protein S27
Cysteine 77 of 40S ribosomal protein S27
6g18 b 64 b 77
A redox-regulated disulphide may form within 40S ribosomal protein S27 between cysteines 64 and 77. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
6g18
Structure name
cryo-em structure of a late human pre-40s ribosomal subunit - state c
Structure deposition date
2018-03-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
9
% buried
46
Peptide accession
P42677
Residue number A
64
Residue number B
77
Peptide name
40S ribosomal protein S27
Ligandability
Cysteine 64 of 40S ribosomal protein S27
Cysteine 77 of 40S ribosomal protein S27
6g5h b 56 b 77
A redox-regulated disulphide may form within 40S ribosomal protein S27 between cysteines 56 and 77. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6g5h
Structure name
cryo-em structure of a late human pre-40s ribosomal subunit - mature
Structure deposition date
2018-03-29
Thiol separation (Å)
10
Half-sphere exposure sum ?
54
Minimum pKa ?
9
% buried
12
Peptide accession
P42677
Residue number A
56
Residue number B
77
Peptide name
40S ribosomal protein S27
Ligandability
Cysteine 56 of 40S ribosomal protein S27
Cysteine 77 of 40S ribosomal protein S27
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