ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Tyrosine-protein kinase ABL2

Intramolecular
Cysteine 1092 and cysteine 1120
Cysteine 1120 and cysteine 1172
A redox-regulated disulphide may form within Tyrosine-protein kinase ABL2 between cysteines 1092 and 1120 (45 and 73 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
2kk1
Structure name
solution structure of c-terminal domain of tyrosine-protein kinase abl2 from homo sapiens, northeast structural genomics consortium (nesg) target hr5537a
Structure deposition date
2009-06-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
49
Peptide accession
P42684
Residue number A
1092
Residue number B
1120
Peptide name
Tyrosine-protein kinase ABL2

Ligandability

Cysteine 1092 of Tyrosine-protein kinase ABL2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1120 of Tyrosine-protein kinase ABL2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tyrosine-protein kinase ABL2 between cysteines 1120 and 1172 (73 and 125 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
2kk1
Structure name
solution structure of c-terminal domain of tyrosine-protein kinase abl2 from homo sapiens, northeast structural genomics consortium (nesg) target hr5537a
Structure deposition date
2009-06-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
10
% buried
60
Peptide accession
P42684
Residue number A
1120
Residue number B
1172
Peptide name
Tyrosine-protein kinase ABL2

Ligandability

Cysteine 1120 of Tyrosine-protein kinase ABL2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1172 of Tyrosine-protein kinase ABL2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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