ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Lysosomal Pro-X carboxypeptidase

Intramolecular
Cysteine 264 and cysteine 343
Cysteine 364 and cysteine 394
Cysteine 233 and cysteine 310
Cysteine 215 and cysteine 372
A redox-regulated disulphide may form within Lysosomal Pro-X carboxypeptidase between cysteines 264 and 343.

Details

Redox score ?
85
PDB code
3n2z
Structure name
the structure of human prolylcarboxypeptidase at 2
Structure deposition date
2010-05-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
39
Minimum pKa ?
nan
% buried
nan
Peptide accession
P42785
Residue number A
264
Residue number B
343
Peptide name
Lysosomal Pro-X carboxypeptidase

Ligandability

Cysteine 264 of Lysosomal Pro-X carboxypeptidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 343 of Lysosomal Pro-X carboxypeptidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lysosomal Pro-X carboxypeptidase between cysteines 364 and 394.

Details

Redox score ?
84
PDB code
3n2z
Structure name
the structure of human prolylcarboxypeptidase at 2
Structure deposition date
2010-05-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P42785
Residue number A
364
Residue number B
394
Peptide name
Lysosomal Pro-X carboxypeptidase

Ligandability

Cysteine 364 of Lysosomal Pro-X carboxypeptidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 394 of Lysosomal Pro-X carboxypeptidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lysosomal Pro-X carboxypeptidase between cysteines 233 and 310.

Details

Redox score ?
83
PDB code
3n2z
Structure name
the structure of human prolylcarboxypeptidase at 2
Structure deposition date
2010-05-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P42785
Residue number A
233
Residue number B
310
Peptide name
Lysosomal Pro-X carboxypeptidase

Ligandability

Cysteine 233 of Lysosomal Pro-X carboxypeptidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 310 of Lysosomal Pro-X carboxypeptidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lysosomal Pro-X carboxypeptidase between cysteines 215 and 372.

Details

Redox score ?
81
PDB code
3n2z
Structure name
the structure of human prolylcarboxypeptidase at 2
Structure deposition date
2010-05-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P42785
Residue number A
215
Residue number B
372
Peptide name
Lysosomal Pro-X carboxypeptidase

Ligandability

Cysteine 215 of Lysosomal Pro-X carboxypeptidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 372 of Lysosomal Pro-X carboxypeptidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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