ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

C-X-C motif chemokine 5

Intramolecular
Cysteine 49 and cysteine 75
Cysteine 51 and cysteine 91
Cysteine 51 and cysteine 75
Cysteine 49 and cysteine 51
Cysteine 49 and cysteine 91
Cysteine 75 and cysteine 91
A redox-regulated disulphide may form within C-X-C motif chemokine 5 between cysteines 49 and 75 (13 and 39 respectively in this structure).

Details

Redox score ?
89
PDB code
2mgs
Structure name
solution structure of cxcl5
Structure deposition date
2013-11-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
40
Minimum pKa ?
nan
% buried
nan
Peptide accession
P42830
Residue number A
49
Residue number B
75
Peptide name
C-X-C motif chemokine 5

Ligandability

Cysteine 49 of C-X-C motif chemokine 5

Cysteine 75 of C-X-C motif chemokine 5

A redox-regulated disulphide may form within C-X-C motif chemokine 5 between cysteines 51 and 91 (15 and 55 respectively in this structure).

Details

Redox score ?
86
PDB code
2mgs
Structure name
solution structure of cxcl5
Structure deposition date
2013-11-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P42830
Residue number A
51
Residue number B
91
Peptide name
C-X-C motif chemokine 5

Ligandability

Cysteine 51 of C-X-C motif chemokine 5

Cysteine 91 of C-X-C motif chemokine 5

A redox-regulated disulphide may form within C-X-C motif chemokine 5 between cysteines 51 and 75 (15 and 39 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
2mgs
Structure name
solution structure of cxcl5
Structure deposition date
2013-11-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
P42830
Residue number A
51
Residue number B
75
Peptide name
C-X-C motif chemokine 5

Ligandability

Cysteine 51 of C-X-C motif chemokine 5

Cysteine 75 of C-X-C motif chemokine 5

A redox-regulated disulphide may form within C-X-C motif chemokine 5 between cysteines 49 and 51 (13 and 15 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
2mgs
Structure name
solution structure of cxcl5
Structure deposition date
2013-11-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
P42830
Residue number A
49
Residue number B
51
Peptide name
C-X-C motif chemokine 5

Ligandability

Cysteine 49 of C-X-C motif chemokine 5

Cysteine 51 of C-X-C motif chemokine 5

A redox-regulated disulphide may form within C-X-C motif chemokine 5 between cysteines 49 and 91 (13 and 55 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
2mgs
Structure name
solution structure of cxcl5
Structure deposition date
2013-11-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P42830
Residue number A
49
Residue number B
91
Peptide name
C-X-C motif chemokine 5

Ligandability

Cysteine 49 of C-X-C motif chemokine 5

Cysteine 91 of C-X-C motif chemokine 5

A redox-regulated disulphide may form within C-X-C motif chemokine 5 between cysteines 75 and 91 (39 and 55 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
2mgs
Structure name
solution structure of cxcl5
Structure deposition date
2013-11-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
P42830
Residue number A
75
Residue number B
91
Peptide name
C-X-C motif chemokine 5

Ligandability

Cysteine 75 of C-X-C motif chemokine 5

Cysteine 91 of C-X-C motif chemokine 5

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