ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Methylenetetrahydrofolate reductase (NADPH)

Intramolecular
Cysteine 193 and cysteine 250
Cysteine 243 and cysteine 250
A redox-regulated disulphide may form within Methylenetetrahydrofolate reductase (NADPH) between cysteines 193 and 250. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
6fcx
Structure name
structure of human 5,10-methylenetetrahydrofolate reductase (mthfr)
Structure deposition date
2017-12-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
49
Peptide accession
P42898
Residue number A
193
Residue number B
250
Peptide name
Methylenetetrahydrofolate reductase (NADPH)

Ligandability

Cysteine 193 of Methylenetetrahydrofolate reductase (NADPH)

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 250 of Methylenetetrahydrofolate reductase (NADPH)

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methylenetetrahydrofolate reductase (NADPH) between cysteines 243 and 250. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
6fcx
Structure name
structure of human 5,10-methylenetetrahydrofolate reductase (mthfr)
Structure deposition date
2017-12-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
62
Minimum pKa ?
11
% buried
65
Peptide accession
P42898
Residue number A
243
Residue number B
250
Peptide name
Methylenetetrahydrofolate reductase (NADPH)

Ligandability

Cysteine 243 of Methylenetetrahydrofolate reductase (NADPH)

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 250 of Methylenetetrahydrofolate reductase (NADPH)

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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