ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Excitatory amino acid transporter 1

Intermolecular
Cysteine 186 and cysteine 186
A redox-regulated disulphide may form between two units of Excitatory amino acid transporter 1 at cysteines 186 and 186. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
7npw
Structure name
cryo-em structure of human excitatory amino acid transporters-1 (eaat1) in potassium buffer
Structure deposition date
2021-02-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
12
% buried
78
Peptide A name
Excitatory amino acid transporter 1
Peptide B name
Excitatory amino acid transporter 1
Peptide A accession
P43003
Peptide B accession
P43003
Peptide A residue number
186
Peptide B residue number
186

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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