ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Platelet-activating factor acetylhydrolase IB subunit beta

Intramolecular
Cysteine 252 and cysteine 281
Cysteine 281 and cysteine 356
A redox-regulated disulphide may form within Platelet-activating factor acetylhydrolase IB subunit beta between cysteines 252 and 281. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
7mt1
Structure name
crystal structure of human platelet-activating factor acetylhydrolase ib subunit beta (pafah1b1)
Structure deposition date
2021-05-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
96
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43034
Residue number A
252
Residue number B
281
Peptide name
Platelet-activating factor acetylhydrolase IB subunit beta

Ligandability

Cysteine 252 of Platelet-activating factor acetylhydrolase IB subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 281 of Platelet-activating factor acetylhydrolase IB subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Platelet-activating factor acetylhydrolase IB subunit beta between cysteines 281 and 356. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7mt1
Structure name
crystal structure of human platelet-activating factor acetylhydrolase ib subunit beta (pafah1b1)
Structure deposition date
2021-05-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
94
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43034
Residue number A
281
Residue number B
356
Peptide name
Platelet-activating factor acetylhydrolase IB subunit beta

Ligandability

Cysteine 281 of Platelet-activating factor acetylhydrolase IB subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 356 of Platelet-activating factor acetylhydrolase IB subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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