a tool for identifying drug-targetable redox-active disulphides

Prostaglandin E2 receptor EP3 subtype

Intramolecular

Cysteine 130 and cysteine 208

A redox-regulated disulphide may form within Prostaglandin E2 receptor EP3 subtype between cysteines 130 and 208.

Details

Redox score ?

84

PDB code

Structure name

crystal structure of ep3 receptor bound to misoprostol-fa

Structure deposition date

2018-08-24

Thiol separation (Å)

2

Half-sphere exposure sum ?

70

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

130

Residue number B

208

Peptide name

Prostaglandin E2 receptor EP3 subtype

Ligandability

Cysteine 130 of Prostaglandin E2 receptor EP3 subtype

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 208 of Prostaglandin E2 receptor EP3 subtype

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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