a tool for identifying drug-targetable redox-active disulphides

Prostaglandin E2 receptor EP2 subtype

Intramolecular

Cysteine 109 and cysteine 187

A redox-regulated disulphide may form within Prostaglandin E2 receptor EP2 subtype between cysteines 109 and 187.

Details

Redox score ?

84

PDB code

Structure name

cryo-em structure of the pge2-bound ep2-gs complex

Structure deposition date

2020-09-01

Thiol separation (Å)

2

Half-sphere exposure sum ?

65

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

109

Residue number B

187

Peptide name

Prostaglandin E2 receptor EP2 subtype

Ligandability

Cysteine 109 of Prostaglandin E2 receptor EP2 subtype

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 187 of Prostaglandin E2 receptor EP2 subtype

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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