ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cell surface glycoprotein MUC18

Intramolecular
Cysteine 365 and cysteine 407
Cysteine 452 and cysteine 499
A redox-regulated disulphide may form within Cell surface glycoprotein MUC18 between cysteines 365 and 407.

Details

Redox score ?
84
PDB code
6lyn
Structure name
cd146 d4-d5/aa98 fab
Structure deposition date
2020-02-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43121
Residue number A
365
Residue number B
407
Peptide name
Cell surface glycoprotein MUC18

Ligandability

Cysteine 365 of Cell surface glycoprotein MUC18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 407 of Cell surface glycoprotein MUC18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cell surface glycoprotein MUC18 between cysteines 452 and 499.

Details

Redox score ?
83
PDB code
6lyn
Structure name
cd146 d4-d5/aa98 fab
Structure deposition date
2020-02-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43121
Residue number A
452
Residue number B
499
Peptide name
Cell surface glycoprotein MUC18

Ligandability

Cysteine 452 of Cell surface glycoprotein MUC18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 499 of Cell surface glycoprotein MUC18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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