ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Netrin receptor DCC

Intramolecular
Cysteine 161 and cysteine 212
Cysteine 61 and cysteine 117
Cysteine 352 and cysteine 400
Cysteine 261 and cysteine 310
Cysteine 261 and cysteine 262
Cysteine 262 and cysteine 310
A redox-regulated disulphide may form within Netrin receptor DCC between cysteines 161 and 212 (123 and 174 respectively in this structure).

Details

Redox score ?
82
PDB code
3laf
Structure name
structure of dcc, a netrin-1 receptor
Structure deposition date
2010-01-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q63155
Residue number A
161
Residue number B
212
Peptide name
Netrin receptor DCC

Ligandability

Cysteine 161 of Netrin receptor DCC

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 212 of Netrin receptor DCC

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor DCC between cysteines 61 and 117 (23 and 79 respectively in this structure).

Details

Redox score ?
82
PDB code
3laf
Structure name
structure of dcc, a netrin-1 receptor
Structure deposition date
2010-01-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q63155
Residue number A
61
Residue number B
117
Peptide name
Netrin receptor DCC

Ligandability

Cysteine 61 of Netrin receptor DCC

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 117 of Netrin receptor DCC

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor DCC between cysteines 352 and 400 (314 and 362 respectively in this structure).

Details

Redox score ?
81
PDB code
3laf
Structure name
structure of dcc, a netrin-1 receptor
Structure deposition date
2010-01-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q63155
Residue number A
352
Residue number B
400
Peptide name
Netrin receptor DCC

Ligandability

Cysteine 352 of Netrin receptor DCC

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 400 of Netrin receptor DCC

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor DCC between cysteines 261 and 310 (223 and 272 respectively in this structure).

Details

Redox score ?
80
PDB code
3laf
Structure name
structure of dcc, a netrin-1 receptor
Structure deposition date
2010-01-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q63155
Residue number A
261
Residue number B
310
Peptide name
Netrin receptor DCC

Ligandability

Cysteine 261 of Netrin receptor DCC

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 310 of Netrin receptor DCC

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor DCC between cysteines 261 and 262 (223 and 224 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
3laf
Structure name
structure of dcc, a netrin-1 receptor
Structure deposition date
2010-01-06
Thiol separation (Å)
7
Half-sphere exposure sum ?
86
Minimum pKa ?
12
% buried
nan
Peptide accession
Q63155
Residue number A
261
Residue number B
262
Peptide name
Netrin receptor DCC

Ligandability

Cysteine 261 of Netrin receptor DCC

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 262 of Netrin receptor DCC

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Netrin receptor DCC between cysteines 262 and 310 (224 and 272 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
3laf
Structure name
structure of dcc, a netrin-1 receptor
Structure deposition date
2010-01-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
85
Minimum pKa ?
12
% buried
nan
Peptide accession
Q63155
Residue number A
262
Residue number B
310
Peptide name
Netrin receptor DCC

Ligandability

Cysteine 262 of Netrin receptor DCC

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 310 of Netrin receptor DCC

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: