a tool for identifying drug-targetable redox-active disulphides

Carbonic anhydrase 7

Intramolecular

Cysteine 56 and cysteine 180

A redox-regulated disulphide may form within Carbonic anhydrase 7 between cysteines 56 and 180 (54 and 178 respectively in this structure).

Details

Redox score ?

82

PDB code

Structure name

the crystal structure of human carbonic anhydrase vii in complex with 4-[(4-fluorophenyl)methyl]-1-piperazinyl]benzenesulfonamide

Structure deposition date

2018-07-17

Thiol separation (Å)

2

Half-sphere exposure sum ?

43

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

56

Residue number B

180

Peptide name

Carbonic anhydrase 7

Ligandability

Cysteine 56 of Carbonic anhydrase 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of Carbonic anhydrase 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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