G protein-coupled receptor kinase 6
Intramolecular
Cysteine 214 and cysteine 260
Cysteine 201 and cysteine 214
Cysteine 203 and cysteine 214
Cysteine 201 and cysteine 474
Cysteine 129 and cysteine 138 L
Cysteine 296 and cysteine 297
Cysteine 201 and cysteine 203
Cysteine 71 and cysteine 80
Cysteine 425 and cysteine 434
Cysteine 201 and cysteine 260
More...Cysteine 57 and cysteine 71
Cysteine 203 and cysteine 260
Cysteine 373 and cysteine 420
2acx A 214 A 260
A redox-regulated disulphide may form within G protein-coupled receptor kinase 6 between cysteines 214 and 260.
Details
Redox score ?
75
PDB code
2acx
Structure name
crystal structure of g protein coupled receptor kinase 6 bound to amppnp
Structure deposition date
2005-07-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
84
Minimum pKa ?
4
% buried
94
Peptide accession
P43250
Residue number A
214
Residue number B
260
Peptide name
G protein-coupled receptor kinase 6
Ligandability
Cysteine 214 of G protein-coupled receptor kinase 6
Cysteine 260 of G protein-coupled receptor kinase 6
2acx A 201 A 214
A redox-regulated disulphide may form within G protein-coupled receptor kinase 6 between cysteines 201 and 214.
Details
Redox score ?
72
PDB code
2acx
Structure name
crystal structure of g protein coupled receptor kinase 6 bound to amppnp
Structure deposition date
2005-07-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
75
Minimum pKa ?
4
% buried
80
Peptide accession
P43250
Residue number A
201
Residue number B
214
Peptide name
G protein-coupled receptor kinase 6
Ligandability
Cysteine 201 of G protein-coupled receptor kinase 6
Cysteine 214 of G protein-coupled receptor kinase 6
2acx B 203 B 214
A redox-regulated disulphide may form within G protein-coupled receptor kinase 6 between cysteines 203 and 214.
Details
Redox score ?
63
PDB code
2acx
Structure name
crystal structure of g protein coupled receptor kinase 6 bound to amppnp
Structure deposition date
2005-07-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
76
Minimum pKa ?
9
% buried
91
Peptide accession
P43250
Residue number A
203
Residue number B
214
Peptide name
G protein-coupled receptor kinase 6
Ligandability
Cysteine 203 of G protein-coupled receptor kinase 6
Cysteine 214 of G protein-coupled receptor kinase 6
2acx A 201 A 474
A redox-regulated disulphide may form within G protein-coupled receptor kinase 6 between cysteines 201 and 474. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
2acx
Structure name
crystal structure of g protein coupled receptor kinase 6 bound to amppnp
Structure deposition date
2005-07-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
31
Peptide accession
P43250
Residue number A
201
Residue number B
474
Peptide name
G protein-coupled receptor kinase 6
Ligandability
Cysteine 201 of G protein-coupled receptor kinase 6
Cysteine 474 of G protein-coupled receptor kinase 6
3nyn B 129 B 138
A redox-regulated disulphide may form within G protein-coupled receptor kinase 6 between cysteines 129 and 138. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
3nyn
Structure name
crystal structure of g protein-coupled receptor kinase 6 in complex with sangivamycin
Structure deposition date
2010-07-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
48
Minimum pKa ?
8
% buried
30
Peptide accession
P43250
Residue number A
129
Residue number B
138
Peptide name
G protein-coupled receptor kinase 6
Ligandability
Cysteine 129 of G protein-coupled receptor kinase 6
Cysteine 138 of G protein-coupled receptor kinase 6
2acx A 296 A 297
A redox-regulated disulphide may form within G protein-coupled receptor kinase 6 between cysteines 296 and 297. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
2acx
Structure name
crystal structure of g protein coupled receptor kinase 6 bound to amppnp
Structure deposition date
2005-07-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
85
Minimum pKa ?
12
% buried
93
Peptide accession
P43250
Residue number A
296
Residue number B
297
Peptide name
G protein-coupled receptor kinase 6
Ligandability
Cysteine 296 of G protein-coupled receptor kinase 6
Cysteine 297 of G protein-coupled receptor kinase 6
3nyn A 201 A 203
A redox-regulated disulphide may form within G protein-coupled receptor kinase 6 between cysteines 201 and 203. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
3nyn
Structure name
crystal structure of g protein-coupled receptor kinase 6 in complex with sangivamycin
Structure deposition date
2010-07-15
Thiol separation (Å)
6
Half-sphere exposure sum ?
75
Minimum pKa ?
13
% buried
92
Peptide accession
P43250
Residue number A
201
Residue number B
203
Peptide name
G protein-coupled receptor kinase 6
Ligandability
Cysteine 201 of G protein-coupled receptor kinase 6
Cysteine 203 of G protein-coupled receptor kinase 6
3nyo A 71 A 80
A redox-regulated disulphide may form within G protein-coupled receptor kinase 6 between cysteines 71 and 80. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
3nyo
Structure name
crystal structure of g protein-coupled receptor kinase 6 in complex with amp
Structure deposition date
2010-07-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
80
Peptide accession
P43250
Residue number A
71
Residue number B
80
Peptide name
G protein-coupled receptor kinase 6
Ligandability
Cysteine 71 of G protein-coupled receptor kinase 6
Cysteine 80 of G protein-coupled receptor kinase 6
2acx B 425 B 434
A redox-regulated disulphide may form within G protein-coupled receptor kinase 6 between cysteines 425 and 434. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
2acx
Structure name
crystal structure of g protein coupled receptor kinase 6 bound to amppnp
Structure deposition date
2005-07-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
52
Peptide accession
P43250
Residue number A
425
Residue number B
434
Peptide name
G protein-coupled receptor kinase 6
Ligandability
Cysteine 425 of G protein-coupled receptor kinase 6
Cysteine 434 of G protein-coupled receptor kinase 6
3nyo B 201 B 260
A redox-regulated disulphide may form within G protein-coupled receptor kinase 6 between cysteines 201 and 260. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
3nyo
Structure name
crystal structure of g protein-coupled receptor kinase 6 in complex with amp
Structure deposition date
2010-07-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
8
% buried
85
Peptide accession
P43250
Residue number A
201
Residue number B
260
Peptide name
G protein-coupled receptor kinase 6
Ligandability
Cysteine 201 of G protein-coupled receptor kinase 6
Cysteine 260 of G protein-coupled receptor kinase 6
2acx A 57 A 71
A redox-regulated disulphide may form within G protein-coupled receptor kinase 6 between cysteines 57 and 71. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
2acx
Structure name
crystal structure of g protein coupled receptor kinase 6 bound to amppnp
Structure deposition date
2005-07-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
13
% buried
93
Peptide accession
P43250
Residue number A
57
Residue number B
71
Peptide name
G protein-coupled receptor kinase 6
Ligandability
Cysteine 57 of G protein-coupled receptor kinase 6
Cysteine 71 of G protein-coupled receptor kinase 6
3nyn A 203 A 260
A redox-regulated disulphide may form within G protein-coupled receptor kinase 6 between cysteines 203 and 260. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
30
PDB code
3nyn
Structure name
crystal structure of g protein-coupled receptor kinase 6 in complex with sangivamycin
Structure deposition date
2010-07-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
83
Minimum pKa ?
13
% buried
91
Peptide accession
P43250
Residue number A
203
Residue number B
260
Peptide name
G protein-coupled receptor kinase 6
Ligandability
Cysteine 203 of G protein-coupled receptor kinase 6
Cysteine 260 of G protein-coupled receptor kinase 6
3nyo A 373 A 420
A redox-regulated disulphide may form within G protein-coupled receptor kinase 6 between cysteines 373 and 420. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
30
PDB code
3nyo
Structure name
crystal structure of g protein-coupled receptor kinase 6 in complex with amp
Structure deposition date
2010-07-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
13
% buried
100
Peptide accession
P43250
Residue number A
373
Residue number B
420
Peptide name
G protein-coupled receptor kinase 6
Ligandability
Cysteine 373 of G protein-coupled receptor kinase 6
Cysteine 420 of G protein-coupled receptor kinase 6
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