ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Tyrosine-protein phosphatase non-receptor type 9

Intramolecular
Cysteine 321 and cysteine 338
Cysteine 531 and cysteine 567
Cysteine 412 and cysteine 515
Cysteine 515 and cysteine 526
A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 9 between cysteines 321 and 338. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
4ge5
Structure name
crystal structure of human protein tyrosine phosphatase ptpn9 (meg2) complex with compound 5
Structure deposition date
2012-08-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
10
% buried
64
Peptide accession
P43378
Residue number A
321
Residue number B
338
Peptide name
Tyrosine-protein phosphatase non-receptor type 9

Ligandability

Cysteine 321 of Tyrosine-protein phosphatase non-receptor type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 338 of Tyrosine-protein phosphatase non-receptor type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 9 between cysteines 531 and 567. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
4ge5
Structure name
crystal structure of human protein tyrosine phosphatase ptpn9 (meg2) complex with compound 5
Structure deposition date
2012-08-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
100
Peptide accession
P43378
Residue number A
531
Residue number B
567
Peptide name
Tyrosine-protein phosphatase non-receptor type 9

Ligandability

Cysteine 531 of Tyrosine-protein phosphatase non-receptor type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 567 of Tyrosine-protein phosphatase non-receptor type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 9 between cysteines 412 and 515. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
4ge6
Structure name
crystal structure of human protein tyrosine phosphatase ptpn9 (meg2) complex with compound 7
Structure deposition date
2012-08-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
12
% buried
100
Peptide accession
P43378
Residue number A
412
Residue number B
515
Peptide name
Tyrosine-protein phosphatase non-receptor type 9

Ligandability

Cysteine 412 of Tyrosine-protein phosphatase non-receptor type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 515 of Tyrosine-protein phosphatase non-receptor type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 9 between cysteines 515 and 526. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
26
PDB code
4ge6
Structure name
crystal structure of human protein tyrosine phosphatase ptpn9 (meg2) complex with compound 7
Structure deposition date
2012-08-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
90
Minimum pKa ?
13
% buried
100
Peptide accession
P43378
Residue number A
515
Residue number B
526
Peptide name
Tyrosine-protein phosphatase non-receptor type 9

Ligandability

Cysteine 515 of Tyrosine-protein phosphatase non-receptor type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 526 of Tyrosine-protein phosphatase non-receptor type 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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