ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Tyrosine-protein kinase ZAP-70

Intramolecular
Cysteine 560 and cysteine 564
Cysteine 564 and cysteine 596
A redox-regulated disulphide may form within Tyrosine-protein kinase ZAP-70 between cysteines 560 and 564.

Details

Redox score ?
74
PDB code
2ozo
Structure name
autoinhibited intact human zap-70
Structure deposition date
2007-02-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
10
% buried
32
Peptide accession
P43403
Residue number A
560
Residue number B
564
Peptide name
Tyrosine-protein kinase ZAP-70

Ligandability

Cysteine 560 of Tyrosine-protein kinase ZAP-70

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 564 of Tyrosine-protein kinase ZAP-70

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tyrosine-protein kinase ZAP-70 between cysteines 564 and 596. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
1u59
Structure name
crystal structure of the zap-70 kinase domain in complex with staurosporine
Structure deposition date
2004-07-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
11
% buried
55
Peptide accession
P43403
Residue number A
564
Residue number B
596
Peptide name
Tyrosine-protein kinase ZAP-70

Ligandability

Cysteine 564 of Tyrosine-protein kinase ZAP-70

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 596 of Tyrosine-protein kinase ZAP-70

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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