ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Tyrosine-protein kinase SYK

Intramolecular
Cysteine 593 and cysteine 597
Cysteine 206 and cysteine 259
A redox-regulated disulphide may form within Tyrosine-protein kinase SYK between cysteines 593 and 597.

Details

Redox score ?
75
PDB code
6hm7
Structure name
crystal structure of spleen tyrosine kinase (syk) in complex with a 2- (phenoxymethyl)pyridine inhibitor
Structure deposition date
2018-09-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
31
Peptide accession
P43405
Residue number A
593
Residue number B
597
Peptide name
Tyrosine-protein kinase SYK

Ligandability

Cysteine 593 of Tyrosine-protein kinase SYK

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 597 of Tyrosine-protein kinase SYK

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tyrosine-protein kinase SYK between cysteines 206 and 259. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
7sa7
Structure name
crystal structure of the apo sh2 domains of syk
Structure deposition date
2021-09-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
10
% buried
60
Peptide accession
P43405
Residue number A
206
Residue number B
259
Peptide name
Tyrosine-protein kinase SYK

Ligandability

Cysteine 206 of Tyrosine-protein kinase SYK

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 259 of Tyrosine-protein kinase SYK

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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