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a tool for identifying drug-targetable redox-active disulphides

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Tumor necrosis factor receptor superfamily member 4

Intermolecular
Cysteine 87 and cysteine 43
Intramolecular
Cysteine 67 and cysteine 81
Cysteine 147 and cysteine 166
Cysteine 2 and cysteine 42
Cysteine 84 and cysteine 99
Cysteine 31 and cysteine 42
Cysteine 87 and cysteine 107
Cysteine 128 and cysteine 141
Cysteine 46 and cysteine 64
Cysteine 109 and cysteine 125
More...
Cysteine 43 and cysteine 56
Cysteine 84 and cysteine 87
Cysteine 84 and cysteine 107
Cysteine 31 and cysteine 43
Cysteine 67 and cysteine 84
Cysteine 107 and cysteine 125
Cysteine 46 and cysteine 81
Cysteine 87 and cysteine 125
Cysteine 2 and cysteine 43
Cysteine 31 and cysteine 56
Cysteine 87 and cysteine 109
Cysteine 64 and cysteine 81
Cysteine 81 and cysteine 84
Cysteine 42 and cysteine 43
Cysteine 2 and cysteine 56
Cysteine 67 and cysteine 99
Cysteine 87 and cysteine 99
Cysteine 107 and cysteine 109
Cysteine 46 and cysteine 67
Cysteine 81 and cysteine 99
Cysteine 125 and cysteine 128
Cysteine 109 and cysteine 141
Cysteine 42 and cysteine 56
Cysteine 43 and cysteine 64
Cysteine 109 and cysteine 128
Cysteine 64 and cysteine 67
Cysteine 125 and cysteine 141
Cysteine 99 and cysteine 107
A redox-regulated disulphide may form between two units of Tumor necrosis factor receptor superfamily member 4 at cysteines 87 and 43. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
2hey
Structure name
crystal structure of murine ox40l bound to human ox40
Structure deposition date
2006-06-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide A name
Tumor necrosis factor receptor superfamily member 4
Peptide B name
Tumor necrosis factor receptor superfamily member 4
Peptide A accession
P43489
Peptide B accession
P43489
Peptide A residue number
87
Peptide B residue number
43

Ligandability

Cysteine 87 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 43 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 67 and 81.

Details

Redox score ?
94
PDB code
6okn
Structure name
ox40r (tnfrsf4) bound to fab 1a7
Structure deposition date
2019-04-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
67
Residue number B
81
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 67 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 81 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 147 and 166.

Details

Redox score ?
92
PDB code
2hey
Structure name
crystal structure of murine ox40l bound to human ox40
Structure deposition date
2006-06-22
Thiol separation (Å)
3
Half-sphere exposure sum ?
nan
Minimum pKa ?
8
% buried
0
Peptide accession
P43489
Residue number A
147
Residue number B
166
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 147 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 166 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 2 and 42 (31 and 42 respectively in this structure).

Details

Redox score ?
90
PDB code
6ogx
Structure name
ternary complex of ox40r (tnfrsf4) bound to fab1 and fab2
Structure deposition date
2019-04-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
2
Residue number B
42
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 2 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 42 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 84 and 99.

Details

Redox score ?
88
PDB code
2hev
Structure name
crystal structure of the complex between ox40l and ox40
Structure deposition date
2006-06-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
84
Residue number B
99
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 84 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 99 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 31 and 42.

Details

Redox score ?
87
PDB code
2hev
Structure name
crystal structure of the complex between ox40l and ox40
Structure deposition date
2006-06-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
40
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
31
Residue number B
42
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 31 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 42 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 87 and 107.

Details

Redox score ?
87
PDB code
6okn
Structure name
ox40r (tnfrsf4) bound to fab 1a7
Structure deposition date
2019-04-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
87
Residue number B
107
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 87 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 107 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 128 and 141.

Details

Redox score ?
86
PDB code
2hey
Structure name
crystal structure of murine ox40l bound to human ox40
Structure deposition date
2006-06-22
Thiol separation (Å)
3
Half-sphere exposure sum ?
63
Minimum pKa ?
9
% buried
7
Peptide accession
P43489
Residue number A
128
Residue number B
141
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 128 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 141 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 46 and 64.

Details

Redox score ?
86
PDB code
2hey
Structure name
crystal structure of murine ox40l bound to human ox40
Structure deposition date
2006-06-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
46
Residue number B
64
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 46 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 64 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 109 and 125.

Details

Redox score ?
84
PDB code
6okn
Structure name
ox40r (tnfrsf4) bound to fab 1a7
Structure deposition date
2019-04-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
109
Residue number B
125
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 109 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 125 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 43 and 56.

Details

Redox score ?
83
PDB code
2hey
Structure name
crystal structure of murine ox40l bound to human ox40
Structure deposition date
2006-06-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
43
Residue number B
56
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 43 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 56 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 84 and 87. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
6okn
Structure name
ox40r (tnfrsf4) bound to fab 1a7
Structure deposition date
2019-04-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
84
Residue number B
87
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 84 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 87 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 84 and 107. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
6okn
Structure name
ox40r (tnfrsf4) bound to fab 1a7
Structure deposition date
2019-04-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
84
Residue number B
107
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 84 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 107 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 31 and 43. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
2hev
Structure name
crystal structure of the complex between ox40l and ox40
Structure deposition date
2006-06-22
Thiol separation (Å)
8
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
31
Residue number B
43
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 31 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 43 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 67 and 84. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
2hev
Structure name
crystal structure of the complex between ox40l and ox40
Structure deposition date
2006-06-22
Thiol separation (Å)
8
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
67
Residue number B
84
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 67 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 84 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 107 and 125. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
2hey
Structure name
crystal structure of murine ox40l bound to human ox40
Structure deposition date
2006-06-22
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
107
Residue number B
125
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 107 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 125 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 46 and 81. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
2hev
Structure name
crystal structure of the complex between ox40l and ox40
Structure deposition date
2006-06-22
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
46
Residue number B
81
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 46 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 81 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 87 and 125. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
2hey
Structure name
crystal structure of murine ox40l bound to human ox40
Structure deposition date
2006-06-22
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
87
Residue number B
125
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 87 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 125 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 2 and 43 (31 and 43 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
6okm
Structure name
human ox40r (tnfrsf4) bound to fab 3c8
Structure deposition date
2019-04-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
2
Residue number B
43
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 2 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 43 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 31 and 56. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
2hev
Structure name
crystal structure of the complex between ox40l and ox40
Structure deposition date
2006-06-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
42
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
31
Residue number B
56
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 31 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 56 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 87 and 109. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
6okn
Structure name
ox40r (tnfrsf4) bound to fab 1a7
Structure deposition date
2019-04-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
87
Residue number B
109
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 87 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 64 and 81. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
6okm
Structure name
human ox40r (tnfrsf4) bound to fab 3c8
Structure deposition date
2019-04-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
64
Residue number B
81
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 64 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 81 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 81 and 84. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
6ogx
Structure name
ternary complex of ox40r (tnfrsf4) bound to fab1 and fab2
Structure deposition date
2019-04-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
81
Residue number B
84
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 81 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 84 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 42 and 43. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
6okm
Structure name
human ox40r (tnfrsf4) bound to fab 3c8
Structure deposition date
2019-04-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
42
Residue number B
43
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 42 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 43 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 2 and 56 (31 and 56 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
6okm
Structure name
human ox40r (tnfrsf4) bound to fab 3c8
Structure deposition date
2019-04-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
41
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
2
Residue number B
56
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 2 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 56 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 67 and 99. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
6ogx
Structure name
ternary complex of ox40r (tnfrsf4) bound to fab1 and fab2
Structure deposition date
2019-04-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
67
Residue number B
99
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 67 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 99 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 87 and 99. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
6okn
Structure name
ox40r (tnfrsf4) bound to fab 1a7
Structure deposition date
2019-04-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
87
Residue number B
99
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 87 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 99 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 107 and 109. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
2hey
Structure name
crystal structure of murine ox40l bound to human ox40
Structure deposition date
2006-06-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
107
Residue number B
109
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 107 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 46 and 67. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
2hey
Structure name
crystal structure of murine ox40l bound to human ox40
Structure deposition date
2006-06-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
46
Residue number B
67
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 46 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 67 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 81 and 99. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
2hev
Structure name
crystal structure of the complex between ox40l and ox40
Structure deposition date
2006-06-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
81
Residue number B
99
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 81 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 99 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 125 and 128. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
6okn
Structure name
ox40r (tnfrsf4) bound to fab 1a7
Structure deposition date
2019-04-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
125
Residue number B
128
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 125 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 128 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 109 and 141. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
2hey
Structure name
crystal structure of murine ox40l bound to human ox40
Structure deposition date
2006-06-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
109
Residue number B
141
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 109 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 141 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 42 and 56. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
2hey
Structure name
crystal structure of murine ox40l bound to human ox40
Structure deposition date
2006-06-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
42
Residue number B
56
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 42 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 56 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 43 and 64. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
6okm
Structure name
human ox40r (tnfrsf4) bound to fab 3c8
Structure deposition date
2019-04-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
43
Residue number B
64
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 43 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 64 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 109 and 128. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
2hev
Structure name
crystal structure of the complex between ox40l and ox40
Structure deposition date
2006-06-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
109
Residue number B
128
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 109 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 128 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 64 and 67. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
2hey
Structure name
crystal structure of murine ox40l bound to human ox40
Structure deposition date
2006-06-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
64
Residue number B
67
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 64 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 67 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 125 and 141. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
6ogx
Structure name
ternary complex of ox40r (tnfrsf4) bound to fab1 and fab2
Structure deposition date
2019-04-03
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43489
Residue number A
125
Residue number B
141
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 125 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 141 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 4 between cysteines 99 and 107. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
2hey
Structure name
crystal structure of murine ox40l bound to human ox40
Structure deposition date
2006-06-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
61
Minimum pKa ?
12
% buried
nan
Peptide accession
P43489
Residue number A
99
Residue number B
107
Peptide name
Tumor necrosis factor receptor superfamily member 4

Ligandability

Cysteine 99 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 107 of Tumor necrosis factor receptor superfamily member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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