a tool for identifying drug-targetable redox-active disulphides

Nicotinamide phosphoribosyltransferase

Intramolecular

Cysteine 39 and cysteine 397

A redox-regulated disulphide may form within Nicotinamide phosphoribosyltransferase between cysteines 39 and 397.

Details

Redox score ?

71

PDB code

Structure name

crystal structure of human nampt in complex with nvp-lvr596

Structure deposition date

2017-10-03

Thiol separation (Å)

4

Half-sphere exposure sum ?

80

Minimum pK_a ?

8

% buried

100

Peptide accession

Residue number A

39

Residue number B

397

Peptide name

Nicotinamide phosphoribosyltransferase

Ligandability

Cysteine 39 of Nicotinamide phosphoribosyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 397 of Nicotinamide phosphoribosyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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