ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Killer cell immunoglobulin-like receptor 2DL1

Intramolecular
Cysteine 49 and cysteine 100
Cysteine 149 and cysteine 198
A redox-regulated disulphide may form within Killer cell immunoglobulin-like receptor 2DL1 between cysteines 49 and 100 (28 and 79 respectively in this structure).

Details

Redox score ?
81
PDB code
1im9
Structure name
crystal structure of the human natural killer cell inhibitory receptor kir2dl1 bound to its mhc ligand hla-cw4
Structure deposition date
2001-05-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43626
Residue number A
49
Residue number B
100
Peptide name
Killer cell immunoglobulin-like receptor 2DL1

Ligandability

Cysteine 49 of Killer cell immunoglobulin-like receptor 2DL1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 100 of Killer cell immunoglobulin-like receptor 2DL1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Killer cell immunoglobulin-like receptor 2DL1 between cysteines 149 and 198 (128 and 177 respectively in this structure).

Details

Redox score ?
81
PDB code
1im9
Structure name
crystal structure of the human natural killer cell inhibitory receptor kir2dl1 bound to its mhc ligand hla-cw4
Structure deposition date
2001-05-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43626
Residue number A
149
Residue number B
198
Peptide name
Killer cell immunoglobulin-like receptor 2DL1

Ligandability

Cysteine 149 of Killer cell immunoglobulin-like receptor 2DL1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 198 of Killer cell immunoglobulin-like receptor 2DL1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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