ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Killer cell immunoglobulin-like receptor 3DL1

Intramolecular
Cysteine 49 and cysteine 95
Cysteine 144 and cysteine 195
Cysteine 244 and cysteine 293
A redox-regulated disulphide may form within Killer cell immunoglobulin-like receptor 3DL1 between cysteines 49 and 95 (28 and 74 respectively in this structure).

Details

Redox score ?
80
PDB code
7k80
Structure name
kir3dl1*001 in complex with hla-a*24:02 presenting the rypltfgw peptide
Structure deposition date
2020-09-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43629
Residue number A
49
Residue number B
95
Peptide name
Killer cell immunoglobulin-like receptor 3DL1

Ligandability

Cysteine 49 of Killer cell immunoglobulin-like receptor 3DL1

Cysteine 95 of Killer cell immunoglobulin-like receptor 3DL1

A redox-regulated disulphide may form within Killer cell immunoglobulin-like receptor 3DL1 between cysteines 144 and 195 (123 and 174 respectively in this structure).

Details

Redox score ?
80
PDB code
5t6z
Structure name
kir3dl1 in complex with hla-b*57:01-tw10
Structure deposition date
2016-09-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43629
Residue number A
144
Residue number B
195
Peptide name
Killer cell immunoglobulin-like receptor 3DL1

Ligandability

Cysteine 144 of Killer cell immunoglobulin-like receptor 3DL1

Cysteine 195 of Killer cell immunoglobulin-like receptor 3DL1

A redox-regulated disulphide may form within Killer cell immunoglobulin-like receptor 3DL1 between cysteines 244 and 293 (223 and 272 respectively in this structure).

Details

Redox score ?
71
PDB code
7k80
Structure name
kir3dl1*001 in complex with hla-a*24:02 presenting the rypltfgw peptide
Structure deposition date
2020-09-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
90
Minimum pKa ?
8
% buried
90
Peptide accession
P43629
Residue number A
244
Residue number B
293
Peptide name
Killer cell immunoglobulin-like receptor 3DL1

Ligandability

Cysteine 244 of Killer cell immunoglobulin-like receptor 3DL1

Cysteine 293 of Killer cell immunoglobulin-like receptor 3DL1

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