ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Killer cell immunoglobulin-like receptor 2DS2

Intramolecular
Cysteine 149 and cysteine 198
Cysteine 49 and cysteine 100
A redox-regulated disulphide may form within Killer cell immunoglobulin-like receptor 2DS2 between cysteines 149 and 198 (128 and 177 respectively in this structure).

Details

Redox score ?
81
PDB code
4n8v
Structure name
crystal structure of killer cell immunoglobulin-like receptor kir2ds2 in complex with hla-a
Structure deposition date
2013-10-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43631
Residue number A
149
Residue number B
198
Peptide name
Killer cell immunoglobulin-like receptor 2DS2

Ligandability

Cysteine 149 of Killer cell immunoglobulin-like receptor 2DS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 198 of Killer cell immunoglobulin-like receptor 2DS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Killer cell immunoglobulin-like receptor 2DS2 between cysteines 49 and 100 (28 and 79 respectively in this structure).

Details

Redox score ?
81
PDB code
7duu
Structure name
crystal structure of hla molecule with an kir receptor
Structure deposition date
2021-01-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
P43631
Residue number A
49
Residue number B
100
Peptide name
Killer cell immunoglobulin-like receptor 2DS2

Ligandability

Cysteine 49 of Killer cell immunoglobulin-like receptor 2DS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 100 of Killer cell immunoglobulin-like receptor 2DS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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