ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Transcription factor GATA-4

Intramolecular
Cysteine 271 and cysteine 274
Cysteine 271 and cysteine 292
Cysteine 271 and cysteine 295
Cysteine 274 and cysteine 292
Cysteine 274 and cysteine 295
Cysteine 292 and cysteine 295
A redox-regulated disulphide may form within Transcription factor GATA-4 between cysteines 271 and 274 (13 and 16 respectively in this structure).

Details

Redox score ?
89
PDB code
2m9w
Structure name
solution nmr structure of transcription factor gata-4 from homo sapiens, northeast structural genomics consortium (nesg) target hr4783b
Structure deposition date
2013-06-20
Thiol separation (Å)
3
Half-sphere exposure sum ?
55
Minimum pKa ?
7
% buried
10
Peptide accession
P43694
Residue number A
271
Residue number B
274
Peptide name
Transcription factor GATA-4

Ligandability

Cysteine 271 of Transcription factor GATA-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 274 of Transcription factor GATA-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription factor GATA-4 between cysteines 271 and 292 (13 and 34 respectively in this structure).

Details

Redox score ?
84
PDB code
2m9w
Structure name
solution nmr structure of transcription factor gata-4 from homo sapiens, northeast structural genomics consortium (nesg) target hr4783b
Structure deposition date
2013-06-20
Thiol separation (Å)
3
Half-sphere exposure sum ?
61
Minimum pKa ?
7
% buried
11
Peptide accession
P43694
Residue number A
271
Residue number B
292
Peptide name
Transcription factor GATA-4

Ligandability

Cysteine 271 of Transcription factor GATA-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 292 of Transcription factor GATA-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription factor GATA-4 between cysteines 271 and 295 (13 and 37 respectively in this structure).

Details

Redox score ?
83
PDB code
2m9w
Structure name
solution nmr structure of transcription factor gata-4 from homo sapiens, northeast structural genomics consortium (nesg) target hr4783b
Structure deposition date
2013-06-20
Thiol separation (Å)
3
Half-sphere exposure sum ?
64
Minimum pKa ?
7
% buried
nan
Peptide accession
P43694
Residue number A
271
Residue number B
295
Peptide name
Transcription factor GATA-4

Ligandability

Cysteine 271 of Transcription factor GATA-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 295 of Transcription factor GATA-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription factor GATA-4 between cysteines 274 and 292 (16 and 34 respectively in this structure).

Details

Redox score ?
81
PDB code
2m9w
Structure name
solution nmr structure of transcription factor gata-4 from homo sapiens, northeast structural genomics consortium (nesg) target hr4783b
Structure deposition date
2013-06-20
Thiol separation (Å)
3
Half-sphere exposure sum ?
56
Minimum pKa ?
9
% buried
8
Peptide accession
P43694
Residue number A
274
Residue number B
292
Peptide name
Transcription factor GATA-4

Ligandability

Cysteine 274 of Transcription factor GATA-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 292 of Transcription factor GATA-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription factor GATA-4 between cysteines 274 and 295 (16 and 37 respectively in this structure).

Details

Redox score ?
78
PDB code
2m9w
Structure name
solution nmr structure of transcription factor gata-4 from homo sapiens, northeast structural genomics consortium (nesg) target hr4783b
Structure deposition date
2013-06-20
Thiol separation (Å)
3
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
nan
Peptide accession
P43694
Residue number A
274
Residue number B
295
Peptide name
Transcription factor GATA-4

Ligandability

Cysteine 274 of Transcription factor GATA-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 295 of Transcription factor GATA-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription factor GATA-4 between cysteines 292 and 295 (34 and 37 respectively in this structure).

Details

Redox score ?
76
PDB code
2m9w
Structure name
solution nmr structure of transcription factor gata-4 from homo sapiens, northeast structural genomics consortium (nesg) target hr4783b
Structure deposition date
2013-06-20
Thiol separation (Å)
3
Half-sphere exposure sum ?
65
Minimum pKa ?
9
% buried
nan
Peptide accession
P43694
Residue number A
292
Residue number B
295
Peptide name
Transcription factor GATA-4

Ligandability

Cysteine 292 of Transcription factor GATA-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 295 of Transcription factor GATA-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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