ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Elongation factor Ts, mitochondrial

Intramolecular
Cysteine 136 and cysteine 328
Cysteine 64 and cysteine 71
A redox-regulated disulphide may form within Elongation factor Ts, mitochondrial between cysteines 136 and 328. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
1xb2
Structure name
crystal structure of bos taurus mitochondrial elongation factor tu/ts complex
Structure deposition date
2004-08-27
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
91
Peptide accession
P43896
Residue number A
136
Residue number B
328
Peptide name
Elongation factor Ts, mitochondrial

Ligandability

Cysteine 136 of Elongation factor Ts, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 328 of Elongation factor Ts, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Elongation factor Ts, mitochondrial between cysteines 64 and 71 (27 and 34 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
2cp9
Structure name
solution structure of rsgi ruh-042, a uba domain from human mitochondrial elongation factor ts
Structure deposition date
2005-05-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
56
Minimum pKa ?
10
% buried
14
Peptide accession
P43897
Residue number A
64
Residue number B
71
Peptide name
Elongation factor Ts, mitochondrial

Ligandability

Cysteine 64 of Elongation factor Ts, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 71 of Elongation factor Ts, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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