ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Mitogen-activated protein kinase 8

Intermolecular
Cysteine 220 and cysteine 220
A redox-regulated disulphide may form between two units of Mitogen-activated protein kinase 8 at cysteines 220 and 220. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
4ux9
Structure name
crystal structure of jnk1 bound to a mkk7 docking motif
Structure deposition date
2014-08-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
100
Peptide A name
Mitogen-activated protein kinase 8
Peptide B name
Mitogen-activated protein kinase 8
Peptide A accession
P45983
Peptide B accession
P45983
Peptide A residue number
220
Peptide B residue number
220

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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