ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Proliferation marker protein Ki-67

Intramolecular
Cysteine 27 and cysteine 49
Cysteine 35 and cysteine 49
Cysteine 27 and cysteine 35
A redox-regulated disulphide may form within Proliferation marker protein Ki-67 between cysteines 27 and 49. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2aff
Structure name
the solution structure of the ki67fha/hnifk(226-269)3p complex
Structure deposition date
2005-07-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
13
% buried
98
Peptide accession
P46013
Residue number A
27
Residue number B
49
Peptide name
Proliferation marker protein Ki-67

Ligandability

Cysteine 27 of Proliferation marker protein Ki-67

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 49 of Proliferation marker protein Ki-67

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proliferation marker protein Ki-67 between cysteines 35 and 49. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
1r21
Structure name
solution structure of human ki67 fha domain
Structure deposition date
2003-09-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
11
% buried
56
Peptide accession
P46013
Residue number A
35
Residue number B
49
Peptide name
Proliferation marker protein Ki-67

Ligandability

Cysteine 35 of Proliferation marker protein Ki-67

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 49 of Proliferation marker protein Ki-67

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proliferation marker protein Ki-67 between cysteines 27 and 35. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
2aff
Structure name
the solution structure of the ki67fha/hnifk(226-269)3p complex
Structure deposition date
2005-07-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
11
% buried
74
Peptide accession
P46013
Residue number A
27
Residue number B
35
Peptide name
Proliferation marker protein Ki-67

Ligandability

Cysteine 27 of Proliferation marker protein Ki-67

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 35 of Proliferation marker protein Ki-67

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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