ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Translation initiation factor IF-2, mitochondrial

Intramolecular
Cysteine 646 and cysteine 692
Cysteine 646 and cysteine 711
Cysteine 692 and cysteine 711
A redox-regulated disulphide may form within Translation initiation factor IF-2, mitochondrial between cysteines 646 and 692. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
3izy
Structure name
mammalian mitochondrial translation initiation factor 2
Structure deposition date
2011-01-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
76
Peptide accession
P46198
Residue number A
646
Residue number B
692
Peptide name
Translation initiation factor IF-2, mitochondrial

Ligandability

Cysteine 646 of Translation initiation factor IF-2, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 692 of Translation initiation factor IF-2, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Translation initiation factor IF-2, mitochondrial between cysteines 646 and 711. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
3izy
Structure name
mammalian mitochondrial translation initiation factor 2
Structure deposition date
2011-01-19
Thiol separation (Å)
7
Half-sphere exposure sum ?
85
Minimum pKa ?
13
% buried
94
Peptide accession
P46198
Residue number A
646
Residue number B
711
Peptide name
Translation initiation factor IF-2, mitochondrial

Ligandability

Cysteine 646 of Translation initiation factor IF-2, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 711 of Translation initiation factor IF-2, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Translation initiation factor IF-2, mitochondrial between cysteines 692 and 711 (79 and 98 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
2crv
Structure name
solution structure of c-terminal domain of mitochondrial translational initiationfactor 2
Structure deposition date
2005-05-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
8
% buried
64
Peptide accession
Q91YJ5
Residue number A
692
Residue number B
711
Peptide name
Translation initiation factor IF-2, mitochondrial

Ligandability

Cysteine 692 of Translation initiation factor IF-2, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 711 of Translation initiation factor IF-2, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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